Research progress on intestinal microbes and their metabolites and autism spectrum disorder

LIU Huan; WANG Suo-ying; LI Yu-qin; SUN Zhi-ming

doi:10.11852/zgetbjzz2021-0627

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (11) : 1216-1220. DOI: 10.11852/zgetbjzz2021-0627

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Research progress on intestinal microbes and their metabolites and autism spectrum disorder

LIU Huan^*, WANG Suo-ying, LI Yu-qin, SUN Zhi-ming

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Abstract

Currently, the underlying mechanisms of etiology and manifestations ofautism spectrum disorder (ASD) are still poorly understood.More and more studies have shown that changes in intestinal microbes and their metabolites (such as short-chain fatty acids, γ-aminobutyric acid, etc.) may be related to the pathogenesis of ASD.Therefore, this paper reviews the studies related to the changes and mechanisms of gut microbes and metabolites in ASD children, and analyzes the possible differences and associations of gut microbes and metabolites between ASD children and healthy children, in order to explore the influence of changes in intestinal microbes and their metabolites on children ASD, and to provide some new ideas for the diagnosis and treatment of ASD.

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autism spectrum disorder / gut microbiota / metabolites / microbiome-gut-brain axis

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LIU Huan, WANG Suo-ying, LI Yu-qin, SUN Zhi-ming. Research progress on intestinal microbes and their metabolites and autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(11): 1216-1220 https://doi.org/10.11852/zgetbjzz2021-0627

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