Research progress on abnormal regulation of gene expression in bronchopulmonary dysplasia

LIN Jie; DUAN Shan

doi:10.11852/zgetbjzz2021-0469

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (6) : 627-631. DOI: 10.11852/zgetbjzz2021-0469

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Research progress on abnormal regulation of gene expression in bronchopulmonary dysplasia

LIN Jie, DUAN Shan

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Abstract

Bronchopulmonary dysplasia (BPD) is one of the most common chronic lung diseases in primarily premature infants.BPD results from an imbalance between lung injury and repair caused by complex interactions between various environmental factors and genetic susceptibility in the developing lung.Studies have shown that BPD pathogenesis is mainly related to the abnormal expressions of inflammatory cytokines, non-coding RNA and signal pathway factors.The abnormal expression of pathogenesis-related genes not only affects the normal development of fetal or neonatal lung, but also impairs lung repair after early injury of the neonatal lung, and influences pulmonary insufficiency alone or cooperatively.Environmental risk factors, such as hyperoxia exposure and inflammation leading to abnormal gene expression, have also been found to be one of the causes of the development of BPD.The interaction between environmental factors and genetic susceptibility is an important mechanism for occurrence and development of BPD.

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bronchopulmonary dysplasia / lung injury and repair / genetic susceptibility / environmental factors

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LIN Jie, DUAN Shan. Research progress on abnormal regulation of gene expression in bronchopulmonary dysplasia[J]. Chinese Journal of Child Health Care. 2022, 30(6): 627-631 https://doi.org/10.11852/zgetbjzz2021-0469

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