Objective To study the changes in serum levels of neurokinin B (NKB) and neuropeptide (Kisspeptin) in girls with idiopathic central precocious puberty (ICPP), and to analyze the correlation with the bone age index, so as to provide reference for assessing the development of these children and the efficacy of treatment. Methods A total of 89 cases of ICPP girls treated in Luoyang Maternal and Child Health Hospital from June 2017 to May 2019 were enrolled in this study, and meanwhile 90 healthy girls were selected as the control group.The levels of serum NKB, Kisspeptin, hormone, bone age and bone age index (BAI) of the participants were detected.The changes of the indicators were compared before and after treatment.Pearson analysis was used to analyze the correlation among serum NKB, Kisspeptin levels and BAI in girls with ICPP before treatment.Logistic regression analysis was used to analyze the influencing factors of bone age index (bone development). Results Compared with those in the control group, the bone age, BAI, uterine volume, serum estrogen, luteinizing hormone, follicle stimulating hormone, prolactin, NKB and Kisspeptin levels were significantly increased in ICPP group (t=14.245, 22.089, 8.321, 18.619, 27.727, 14.241, 28.152,17.655,9.668, P<0.05).Pearson correlation analysis showed that serum NKB and Kisspeptin levels were positively correlated with BAI (r=0.591, 0.634, P<0.05).Logistic regression analysis showed that NKB(OR=2.009, 95%CI:1.105 - 3.654, P=0.038) and Kisspeptin(OR=1.859, 95%CI:1.341 - 2.578, P=0.017) are factors that affect bone age index (bone development).Compared with those before treatment, the levels of serum estrogen, luteinizing hormone, follicle stimulating hormone, prolactin, NKB, Kisspeptin and BAI in ICPP girls were significantly decreased after treatment (t=14.367, 22.482, 9.465, 23.807, 13.664, 8.642, 7.100, P<0.05). Conclusions The serum levels of NKB and Kisspeptin in ICPP girls are increasing, which is related to the patient's bone age index and can be used as markers to assess the sexual development of ICPP girls and the effect of treatment.
Key words
neurokinin B /
kisspeptin /
idiopathic central precocious puberty /
bone age index /
girls /
correlation /
serum
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