Objective To develop a screening questionnaire of autism suitable for children with Chinese cultural background, and to test its reliability and validity. Methods Screening Questionnaire of Autism in Toddlers (SQAT) was compiled based on the relevant research results and DSM-5 diagnostic criteria for autism spectrum disorder (ASD).Totally 238 children in outpatients or physical examination and 392 children in rehabilitation training institutions were selected for the SQAT assessment, 28 of them were retested 2 to 4 weeks later, and some children were tested by criteria scale.The item selection, reliability and validity of the questionnaire were made by expert evaluation, item analysis, correlation analysis, factor analysis and ROC analysis. Results Thirteen items with good responsiveness (0.394 - 0.626), discrimination (0.465 - 0.697) and common factor loading (0.317 - 0.605) were selected to form the SQAT, which included social and behavioral components.The S-CVI/UA and S-CVI/Ave of expert evaluation was 0.99 and 0.89, respectively.The Cronbach'α coefficients, split-half reliability and retest reliability of the total scale and two components were 0.770 - 0.851, 0.838 - 0.890 and 0.601 - 0.734, respectively.Exploratory factor analysis extracted two factors with eigenvalue >1 and accounted for 50.2% of variance, and confirmatory factor analysis showed that the two factor model of SQAT had a good fit (RMSEA=0.055, NFI=0.872, IFI=0.926, CFI=0.924).The correlation coefficients of total and component scores with ABC and M-CHAT-R/F were 0.518 - 0.656 and 0.305 - 0.833, respectively (P<0.01), and total score of ASD group (23.26 ± 4.73) was higher than that of GDD group (17.32 ± 3.39) and TD group (15.85 ± 2.01) (P<0.01).The sensitivity, specificity and positive predictive value of the SQAT in screening ASD were 82.00%, 80.60% and 96.46%, respectively. Conclusion SQAT has good reliability and validity, which can be used as a preliminary screening tool for children with ASD.
Key words
autism spectrum disorder /
screening questionnaire /
reliability /
validity /
infants and toddlers
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