Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder

QU Ling-ling; WAN Yan-nan; CHENG Qian

doi:10.11852/zgetbjzz2021-0249

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (8) : 884-889. DOI: 10.11852/zgetbjzz2021-0249

Meta Analysis

Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder

QU Ling-ling, WAN Yan-nan, CHENG Qian

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Abstract

Objective To systematically interview the effects of gluten-free and casein-free (GFCF) diets in children with autism spectrum disorder(ASD), in order to provide scientific reference for clinical treatment. Methods Literature searches were conducted in PubMed, EBSCO, Cochrane Library, SpringerLink, Vip, Wan-fang and China National Knowledge Internet (CNKI) database. Only randomized controlled trails were included, and the quality of the literature was evaluated. Results A total of 7 studies with 181 ASD samples were included. Seven articles all studied the effects of GFCF diets on core symptoms of ASD, five articles showed that the GFCF diets could not improve the core symptoms of ASD. Two articles studied the effects of GFCF diets on gastrointestinal symptoms of ASD, but neither of them showed that GFCF diets could improve the gastrointestinal symptoms of ASD. Conclusion GFCF diets could not improve the core symptoms and gastrointestinal symptoms of ASDchildren.

Key words

autism spectrum disorder / diets / core symptoms / gastrointestinal symptoms

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QU Ling-ling, WAN Yan-nan, CHENG Qian. Systematic review on the effect of gluten-free and casein-free diets inchildren with autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(8): 884-889 https://doi.org/10.11852/zgetbjzz2021-0249

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