Analysis of correlation between resting-state functional magnetic resonance imaging regional homogeneity signals and attention cognition in school-age children

ZHANG Ling-yun; REN Yan-hong; WANG Xiao-wen; SHI Cong-cong; YANG Shuo

doi:10.11852/zgetbjzz2021-0167

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (12) : 1282-1286. DOI: 10.11852/zgetbjzz2021-0167

Analysis of correlation between resting-state functional magnetic resonance imaging regional homogeneity signals and attention cognition in school-age children

ZHANG Ling-yun^*, REN Yan-hong, WANG Xiao-wen, SHI Cong-cong, YANG Shuo

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Abstract

Objective To investigate the correlation of spontaneous brain activity and continuous operation task (CPT) performance with regional homogeneity (ReHo) of the resting-state functional magnetic resonance imaging, and to explore the neural basis of children′s attention function. Methods From May 2018 to October 2019, 33 children were recruited from the physical examination department of Henan Children′s Hospital, whose blood oxygenation level dependent (BOLD) signal and task behavioral performance(reaction time, RT) were acquired.ReHo is calculated by BOLD signal, which reflects the synchronization of neuron activation in brain regions.Pearson correlation analysis between the ReHo values and the RT was performed in a voxel-wise manner to get the significant ReHo-RT correlation map. Results Significant negative ReHo-RT correlations were observed in right middle temporal gyrus (BA20, r=-0.84), right medial prefrontal lobe (BA32, r=-0.83), right inferior parietal lobule (BA19, r=-0.78), left precuneus (BA7, r=-0.84) and right lingual gyrus (BA17, r=-0.82).Significant positive ReHo-RT correlations were observed in bilateral middle frontal gyrus (BA11, r=0.87), left precentral gyrus (BA6, r=0.84), left thalamus (r=0.72), left posterior cerebellar lobe (r=0.72). Conclusions There is a significant correlation between the spontaneous activity of bilateral middle frontal gyrus and default network, left anterior central gyrus, left posterior cerebellar lobe, left thalamus and right lingual gyrus and the reaction time of children′s performance in CPT task, suggesting that the middle frontal gyrus plays an important role in the maintenance of attention function, and the appropriate activity level of default network is more conducive to the completion of executive function.The cortical-cerebellar-thalamus-cortical circuit may be the underlying neural basis for school-age children′s attention and executive function.

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resting-state functional magnetic resonance imaging / regional homogeneity / continuous operation task / reaction time

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ZHANG Ling-yun, REN Yan-hong, WANG Xiao-wen, SHI Cong-cong, YANG Shuo. Analysis of correlation between resting-state functional magnetic resonance imaging regional homogeneity signals and attention cognition in school-age children[J]. Chinese Journal of Child Health Care. 2022, 30(12): 1282-1286 https://doi.org/10.11852/zgetbjzz2021-0167

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