Analysis of clinical and electroencephalogram features in children with autism spectrum disorder combined with epilepsy

DU Ya-kun; WANG Xia; CHEN Fang; LI Bao-guang; SUN Chen-bo; SUN Su-zhen

doi:10.11852/zgetbjzz2021-0141

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (4) : 427-430. DOI: 10.11852/zgetbjzz2021-0141

Clinical Research

Analysis of clinical and electroencephalogram features in children with autism spectrum disorder combined with epilepsy

DU Ya-kun, WANG Xia, CHEN Fang, LI Bao-guang, SUN Chen-bo, SUN Su-zhen

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Abstract

Objective To analyze the clinical and electroencephalogram(EEG)features in children with autism spectrum disorder(ASD)combined with epilepsy,in order to provide clues for optimizing the clinical treatment of these children. Methods A total of 120 children with ASD combined with seizures in Children's Hospital of Hebei Province from January 2017 to December 2019 were enrolled in this study. Their clinical features and EEG features were retrospectively analyzed. Results The features of seizures in ASD children combined with epilepsy were mainly focal seizures(83.3%),which peaked at 5 to 7 years old,and the proportion of children with low intelligence level was high.EEG discharges were most common in the frontal region(40%) and temporal area(30%).The intelligence level of the patients was negatively correlated with the interictal epileptiform activity(IEA)(r=-0.736,P<0.001). Conclusions ASD combined with epilepsy has its own clinical features.As a method to evaluate brain function,EEG has a high application value in the diagnosis and treatment of diseases.

Key words

autism spectrum disorder / epilepsy / electroencephalogram / intelligence level / children

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DU Ya-kun, WANG Xia, CHEN Fang, LI Bao-guang, SUN Chen-bo, SUN Su-zhen. Analysis of clinical and electroencephalogram features in children with autism spectrum disorder combined with epilepsy[J]. Chinese Journal of Child Health Care. 2022, 30(4): 427-430 https://doi.org/10.11852/zgetbjzz2021-0141

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