Objective To explore the characteristics of brain network signal transmission in children with nocturnal enuresis (NE) in different frequency bands, and to find abnormal brain areas, so as to provide theoretical basis for follow-up precision treatment. Methods A case-control study was adopted. According to the criteria of the International Children′s Continence Society (ICCS), 129 children with NE and 37 children without enuresis in Shanghai Children′s Medical Center were enrolled in this study from 2016 to 2018. Degree centrality (DC) was analyzed in the typical band (0.01-0.08 Hz) and in slow 5 (0.010-0.027 Hz). T test were used to compare the differences between the two groups in the different frequency bands. Results were corrected using Gaussian random field (GRF) theory (P<0.05 for voxels and P<0.05 for clusters). Results In the typical frequency band, children with enuresis had significantly higher DCs in the left rolandic operculum (t=4.469 9, GRF corrected P<0.05 for voxel, P<0.05 for clusters), right rolandic operculum(t=4.351 6, GRF corrected P<0.05 for voxel, P<0.05 for clusters) and left middle cingulate gyrus (t=4.139 7, GRF corrected P<0.05 for voxel, P<0.05 for clusters), while lower DCs in the right gyrus rectus (t＝-4.127 2, GRF corrected P<0.05 for voxel, P<0.05 for clusters) and the left middle frontal gyrus (t＝-4.835 5, GRF corrected P<0.05 for voxel, P<0.05 for clusters). In sub-bands, DC values of children with nocturnal enuresis were increased in the left thalamus (t=3.905 4, GRF corrected P<0.05 for voxel, P<0.05 for clusters) and decreased in the right superior frontal gyrus, orbital part (t＝-4.509 6, GRF corrected P<0.05 for voxel, P<0.05 for clusters). Conclusions Brain regions with abnormal DC values in band 5 are directly related to the regulation of voiding function in children, according to previous study. And the function of brain regions in the typical band needs to be further investigated. Increased DC values in the left thalamus and decreased DC values in the frontal middle gyrus may affect the transmission of information in the voiding network of children, which may contribute to the occurrence of nocturnal enuresis.
Key words
nocturnal enuresis /
brain network /
degree centrality /
frequency-dependent /
children
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