Objective To systematically analyze of the risk factors of intracranial hemorrhage in very low birth weight infants(VLBWI) and extremely low birth weight infants(ELBWI), in order to provide reference for early prevention and clinical decision-making. Methods Literatures were searched in China National Knowledge Network, China Biomedical Literature Database (CBM), Wanfang Database, VIP Database, Cochrane Library, PubMed, Web of Science, EMBASE from the establishment of the database to to September 18, 2020. Literatures were retrieved and selected according to the inclusion and exclusion criteria. Finally RevMan 5.3 was used to conduct Meta-analysis. Results Totally 13 literatures met the inclusion criteria. The cumulative number of cases was 790, and the number of controls was 1 871. Meta-analysis showed that the risk factors for intracranial hemorrhage in VLBWI and ELBWI included intrauterine distress or asphyxia(OR=2.52,95%CI: 1.98 - 3.21), application of mechanical ventilation (OR=3.35,95%CI:2.56 - 4.38), mechanical ventilation time ＞3 days (OR=10.29,95%CI:3.69 - 28.66), coagulation mechanism disorder(OR=3.42,95%CI:1.80 - 6.48),neonatal necrotizing enterocolitis (OR=3.79, 95%CI:1.92 - 7.50) and gestational age ＜29 weeks (OR=2.45, 95%CI:1.65 - 3.64), and the protective factor is antenatal use of glucocorticoids (OR=0.35, 95%CI:0.22 - 0.56). It was found that vaginal delivery had no significant influence on ICH of VLBWI and ELBWI. Conclusions Intrauterine distress or asphyxia, application of mechanical ventilation, mechanical ventilation time ＞3 days, coagulation mechanism disorder, neonatal necrotizing enterocolitis and gestational age ＜29 weeks are closely related to intracranial hemorrhage in VLBWI and ELBWI. Prenatal glucocorticoids can reduce the incidence of intracranial hemorrhage in VLBWI and ELBWI.
Key words
very low birth weight infants /
extremely low birth weight infants /
intracranial hemorrhage
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