New progress in the pathogenesis of neonatal necrotizing enterocolitis

LIU Na; LI Zhong-liang; ZHANG Chun-lei; LI Xue-feng; ZHANG Cheng-yuan; ZHANG Xue-bo

doi:10.11852/zgetbjzz2020-2064

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (12) : 1309-1312. DOI: 10.11852/zgetbjzz2020-2064

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New progress in the pathogenesis of neonatal necrotizing enterocolitis

LIU Na, LI Zhong-liang, ZHANG Chun-lei, LI Xue-feng, ZHANG Cheng-yuan, ZHANG Xue-bo

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Abstract

Necrotizing enterocolitis (NEC) is one of the diseases with high morbidity and mortality in neonates. Although the clinical diagnosis, treatment and nursing of newborns have improved, the unclear pathogenesis is still the main reason that limits the prognosis of NEC. In recent years, new progress has been made in the research of the pathogenesis of NEC, including the modulation of vascular endothelial growth factor, the signal transduction of Toll-like receptors, the discovery of potential biomarkers of NEC through metabolomics, probing for genetic predispositions to NEC susceptibility, determining mechanistic relations between anemia, intestinal flora imbalance and NEC. In-depth understanding of the pathogenesis of NEC will help to further improve the diagnosis and treatment of this disease. In this article, these new insights will be reviewed.

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necrotizing enterocolitis / pathogenesis / newborn

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LIU Na, LI Zhong-liang, ZHANG Chun-lei, LI Xue-feng, ZHANG Cheng-yuan, ZHANG Xue-bo. New progress in the pathogenesis of neonatal necrotizing enterocolitis[J]. Chinese Journal of Child Health Care. 2021, 29(12): 1309-1312 https://doi.org/10.11852/zgetbjzz2020-2064

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