Objective To investigate the correlation between vitamin D level at birth and hypoxic ischemic encephalopathy (HIE) in premature infants, so as to provide reference for its prevention. Methods From June 2018 to June 2020, 25 premature infants diagnosed with HIE (HIE group) and 138 children without HIE (non-HIE group) were selected as study objects from Pediatrics of Boluo County Maternal and Child Health Care Family Planning Service Center. 25-(OH)D level of umbilical artery blood at birth and maternal 25-(OH)D level were compared between the two groups. The risk factors for HIE were analyzed by Logistic regression. Results Compared with the non-HIE group, HIE group had a higher incidence of intrauterine distress(χ2=46.875), a lower Apgar score at 1min(t=10.854) and a longer mechanical ventilation time(t=7.166), and the differences were statistically significant(P＜0.01). The level of 25-(OH)D of cord blood at birth and maternal 25-(OH)D level in the HIE group were significantly lower than those in the non-HIE group(t=2.346, 2.092, P＜0.05). And the proportion of vitamin D deficiency or insufficiency at birth was significantly higher than that in the non-HIE group (64% vs. 39.9%, χ2=5.019,P＜0.05). Maternal 25-(OH)D level in the two groups was positively correlated with the 25-(OH)D level of premature infants at birth (HIE group r=0.825, non-HIE group r=0.682, P＜0.05). Logistic regression analysis showed that the risk factors for HIE included intrauterine distress (OR=1.137, 95%CI:1.105-1.209), 1min Apgar score＜5(OR=1.170, 95%CI:1.085-1.443), long mechanical ventilation time(OR=1.431, 95%CI: 1.275-1.610) and low 25-(OH)D level(Mother OR=1.234,95%CI:1.010-1.511;Preterm OR=1.505,95%CI:1.191-1.899). Conclusions The proportion of premature infants with deficiency or insufficient vitamin D at birth is 50.9% (83/163). Low vitamin D level at birth and low maternal vitamin D level are high risk factors for premature infants with HIE, and vitamin D supplementation during pregnancy and after birth should be paid attention to.
Key words
vitamin D deficiency /
hypoxic ischemic encephalopathy /
premature infants
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References
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