Research advances in immunopathological mechanism of Tourette syndrome

ZHANG Xiao-ling; LIU Xiu-mei

doi:10.11852/zgetbjzz2020-2044

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (4) : 409-412. DOI: 10.11852/zgetbjzz2020-2044

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Research advances in immunopathological mechanism of Tourette syndrome

ZHANG Xiao-ling^*, LIU Xiu-mei

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Abstract

Increasing studies focus on the association between immune reactions and the onset of Tourette syndrome (TS).This article reviews the immunological mechanism involved in the development of TS.Immune dysfunction plays an important role in the pathophysiology of TS and may be the characteristic of a specific subgroup in TS heterogeneity spectrum disorder.Different distribution and expression of immune cell subpopulations, immune cytokines or genes affect the immune response in patients with TS.Hyperdopamine function, increased microglia activation and autoantibodies are involved in the immunopathological mechanisms of TS development.Therefore, large-scale prospective studies are warranted to further explore the causal relationship between the neuropsychiatric symptoms and immune dysfunction of TS.

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Tourette syndrome / immunity / regulatory T cells / nerve / microglia

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ZHANG Xiao-ling, LIU Xiu-mei. Research advances in immunopathological mechanism of Tourette syndrome[J]. Chinese Journal of Child Health Care. 2022, 30(4): 409-412 https://doi.org/10.11852/zgetbjzz2020-2044

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