Objective To analyze the influence of gestational age and postnatal age on thyroid function indexes in premature infants, in order to establish a reference interval for thyroid function for premature infants based on gestational age and postnatal age. Methods The levels of thyroid stimulating hormone (TSH), thyroxine (T4), free thyroxine (FT4) and triiodothyronine (T3) of premature infants in neonatal department of Longgang Central Hospital from May 2017 to May 2020 were collected. Infants were divided into early preterm infants, mid-term premature infants and late premature infants according to gestational age and postnatal age. The levels of thyroid function index in each group were compared, and the changes of each index with gestational age and postnatal age were analyzed. Results A total of 497 premature infants were included. The early, mid-term and late premature infants were 206, 128, and 163 cases, respectively. 1) The levels of thyroid function indexes of early premature infants were significantly different from those of mid-late and late preterm infants(P＜0.05), but the difference was not significant between mid-late and late preterm infants(P＞0.05). 2) The T4, FT4 and T3 levels of early preterm infants were significantly different among infants with different gestational ages(H=36.588, 32.381, 43.021, P<0.05), while the significant difference was not found in TSH level(P＞0.05). 3)The T4, FT4 and T3 levels of premature infants were significantly different between 7—14 days group and 14—28 days group (Z=8.706, 6.904, 9.497,P＜0.05), but the significant difference was not found in TSH level(P＞0.05). 4) The T4, FT4, T3 level of premature infants was positively correlated with gestational age and postnatal age, but the correlation was not significant between TSH level and gestational age and postnatal age. Conclusion The levels of T4, FT4 and T3 in early preterm infants are positively correlated with gestational age and postnatal age, so the reference interval of thyroid function for preterm infants should be established based on gestational age and postnatal age.
Key words
thyroid function /
preterm infant /
gestational ages /
postnatal age
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