Blood lead level and its correlation with social functions in school-age children with attention deficit/hyperactivity disorder

DONG Shuang*; JI Yi-ting*; WANG Dan; MAO Guang-hui; YAN Chong-huai; CAI Shi-zhong; CHEN Yan

doi:10.11852/zgetbjzz2020-2006

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (2) : 207-211. DOI: 10.11852/zgetbjzz2020-2006

Blood lead level and its correlation with social functions in school-age children with attention deficit/hyperactivity disorder

DONG Shuang^*, JI Yi-ting^*, WANG Dan, MAO Guang-hui, YAN Chong-huai, CAI Shi-zhong, CHEN Yan

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Abstract

Objective To investigate the environmental lead exposure of school-age children with attention/deficit hyperactivity disorder(ADHD),and to further analyze the correlation between the lead exposure levels of ADHD children in different years and subtypes,as well as the social functions under different blood lead levels. Methods A total of 4 590 ADHD children were recruited as ADHD group from January 2016 to December 2019 in the Department of Child Health Care in Children′s Hospital of Soochow University. Meanwhile,2 264 children with inattention and/or impulsive hyperactivity symptoms but not meeting the diagnostic criteria were selected as non-ADHD group. Fasting venous blood was collected from all children in the morning,and the blood lead level was determined by atomic absorption spectrometry. All children′s social functions were evaluated by Weiss Functional Impairment Rating Scale-Parent Report(WFIRS-P). Results From 2016 to 2019,the overall blood lead level of ADHD children showed a downward trend year by year. The blood lead level of children in ADHD group was higher than that of children in non-ADHD group(t=2.659,P=0.008). The proportion of blood lead level ≥50 μg/L in children with combined ADHD was the highest. The blood lead level of children with combined ADHD was higher than that of predominantly inattentive ADHD group and predominantly hyperactive/impulsive ADHD group(H=14.629,P=0.001). There was no significant correlation between blood lead level and six dimensions of social functions in ADHD children, but the score of social activities was significanty higher in non-ADHD children with blood lead level<50 μg/L(t=2.016,P<0.05). Conclusions In recent years,the level of lead exposure in children shows a downward trend. For children with inattention and/or impulsive hyperactivity as the main symptoms,attention still should be paid to low level of lead exposure.

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attention deficit/hyperactivity disorder / blood lead level / children / social function / environment

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DONG Shuang^*, JI Yi-ting^*, WANG Dan, MAO Guang-hui, YAN Chong-huai, CAI Shi-zhong, CHEN Yan. Blood lead level and its correlation with social functions in school-age children with attention deficit/hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2022, 30(2): 207-211 https://doi.org/10.11852/zgetbjzz2020-2006

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