Meta-analysis on the association between brain derived neurotrophic factor Val66Met gene polymorphism and attention deficit hyperactivity disorder

CHEN Wen-cai; ZUO Fei-yan; WAN Ying; WANG Mei-ling

doi:10.11852/zgetbjzz2020-1952

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (3) : 301-305. DOI: 10.11852/zgetbjzz2020-1952

Meta-analysis on the association between brain derived neurotrophic factor Val66Met gene polymorphism and attention deficit hyperactivity disorder

CHEN Wen-cai, ZUO Fei-yan, WAN Ying, WANG Mei-ling

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Abstract

Objective To evaluate the association between brain derived neurotrophic factor (BDFN) Val66Met gene polymorphism and attention deficit/hyperactivity disorder (ADHD), in order to provide clues for research on genetic etiology of ADHD. Methods The CNKI, WanFang, PubMed, EMbase and Web of Science databases were conducted to collect published case-control studies on the association between Val66Met and ADHD from establishment to April 2020.Two reviewers independently screened the literature, extracted the data, and assessed the quality of included studies.RevMan 5.3 and Stata 11.0 software then were used to perform meta-analysis. Results Totally 9 articles were included with 8 458 samples (including 4 247 cases and 4 211 controls).Meta-analysis indicated that rs6265 was not associated with the susceptibility to ADHD (dominant gene model: OR=0.96, 95%CI:0.87 - 1.06, P=0.40 ; recessive model: OR=1.01, 95%CI:0.88 - 1.15, P=0.92; additive model: OR=0.95,95%CI:0.85 - 1.08,P=0.45). Conclusion The polymorphism of BDNF Val66Met gene is not associated with susceptibility to ADHD.

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brain derived neurotrophic factor(BDNF) / Val66Met / attention deficit/hyperactivity disorder / Meta-analysis

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CHEN Wen-cai, ZUO Fei-yan, WAN Ying, WANG Mei-ling. Meta-analysis on the association between brain derived neurotrophic factor Val66Met gene polymorphism and attention deficit hyperactivity disorder[J]. Chinese Journal of Child Health Care. 2022, 30(3): 301-305 https://doi.org/10.11852/zgetbjzz2020-1952

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