Research progress on the risk factors of neonatal sepsis

FENG Mei-yuan; FU Zhong-qiu

doi:10.11852/zgetbjzz2020-1902

PDF(522 KB)

Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (12) : 1329-1332. DOI: 10.11852/zgetbjzz2020-1902

Review

Research progress on the risk factors of neonatal sepsis

FENG Mei-yuan, FU Zhong-qiu

Author information +

History +

Abstract

Neonatal sepsis can cause infection in all systems of the body, which is the main cause of neonatal infectious diseases and death. In recent years, different views have been put forward around the risk factors of neonatal sepsis. In addition to preterm birth and low birth weight, vitamin D deficiency is also considered as one of the risk factors for early and late onset sepsis. Premature rupture of membranes and chorionic amnitis, previously considered as risk factors for early sepsis, have also been disputed at present. This article reviews the progress of the above factors and the irrational use of antibiotics, invasive procedures and parenteral nutrition, which lead to late-onset sepsis, as well as other influencing factors, with the aim of providing measures for the prevention of neonatal sepsis.

Key words

early-onset sepsis / late-onset sepsis / newborn

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

FENG Mei-yuan, FU Zhong-qiu. Research progress on the risk factors of neonatal sepsis[J]. Chinese Journal of Child Health Care. 2021, 29(12): 1329-1332 https://doi.org/10.11852/zgetbjzz2020-1902

References

[1] 中华医学会儿科学分会新生儿学组,中国医师协会新生儿科医师分会感染专业委员会.新生儿败血症诊断及治疗专家共识(2019年版)[J].中华儿科杂志,2019,57(4):252-257.
[2] Tsehaynesh G,Feleke M,Setegn E,et al.Bacterial etiologic agents causing neonatal sepsis and associated risk factors in Gondar, Northwest Ethiopia[J].BMC Pediatr,2017,17(1):137-147.
[3] Procianoy RS,Silveira RC.The challenges of neonatal sepsis management[J].J Pediatr (Rio J),2019.doi:10.1016/j.jped.2019.10.004.
[4] Fleischmann-Struzek C,Goldfarb DM,Schlattmann P,et al.The global burden of paediatric and neonatal sepsis:a systematic review[J].Lancet Respir Med,2018,6:223-230.
[5] Jiang S,Yang C,Yang C,et al.Epidemiology and microbiology of late-onset sepsis among preterm infants in China,2015-2018:A cohort study[J].Int J Infect Dis,2020,96:1-9.
[6] Jiang S,Hong L,Gai J,et al.Early-onset sepsis among preterm neonates in China,2015 to 2018[J].Pediatr Infect Dis J,2019,38:1236-1241.
[7] Dutta S,Reddy R,Sheikh S,et al.Intrapartum antibiotics and risk factors for early onset sepsis[J].Arch Dis Child Fetal Neonatal Ed,2010,95:99-103.
[8] Jiang Z,Ye GY. 1∶4 matched case-control study on influential factor of early onset neonatal sepsis[J].Eur Rev Med Pharmacol Sci,2013,17(18):2460-2466.
[9] Collins A,Weitkamp J,Wynn JL.Why are preterm newborns at increased risk of infection?[J].Arch Dis Child Fetal Neonatal Ed,2018,103: 391-394.
[10] Strunk T,Currie A,Richmond P,et al.Innate immunity in human newborn infants:prematurity means more than immaturity[J].J Matern Fetal Neonatal Med,2011,24(1):25-31.
[11] Carbone F,Montecucco F,Sahebkar A.Current and emerging treatments for neonatal sepsis[J].Expert Opin Pharmacother,2020,215(5):1-9.
[12] 张怡娟,郭卫芳,于方,等.早产儿免疫相关因素的分析[J].河南诊断与治疗杂志,2002,16(4):253-254.
[13] Youssef DA,Miller CWT, Abbassi AM,et al.Antimicrobial implications of vitamin D[J].Dermato-endocrinology,2011,3(4):220-229.
[14] Sadeghi K,Wessner B,Laggner U,et al.Vitamin D3 down-regulates monocyte TLR expression and triggers hyporesponsiveness to pathogen-associated molecular patterns[J].Eur J Immunol,2006,36: 361-370.
[15] Clancy N, Onwuneme C,Carroll A.Vitamin D and neonatal immune function[J].J Matern Fetal Neonatal Med,2013,267(7):639-646.
[16] Cizmeci MN,Kanburoglu MK,Akelma AZ,et al.Cord-blood 25-hydroxyvitamin D levels and risk of early-onset neonatal sepsis:a case-control study from a tertiary care center in Turkey[J].Eur J Pediatr,2015,1746(6): 809-815.
[17] 杨玲蓉,李桦,杨涛义,等.维生素 D 缺乏与新生儿早发型败血症的相关性研究[J].中国当代儿科杂志,2016,18(9):791-795.
[18] Agrawal A, Gupta A, Shrivastava J.Role of vitamin-D deficiency in term neonates with late-onset sepsis:A case-control study[J].J Trop Pediatr,2019,656:1-8.
[19] Dhandai R,Jajoo M,Singh A,et al.Association of vitamin D deficiency with an increased risk of late-onset neonatal sepsis[J].Paediatr Int Child Health,2018,383(3):1-5.
[20] 汪莉,王杨.胎膜早破与晚发型败血症和(或)新生儿坏死性小肠结肠炎的临床观察[J].中华妇幼临床医学杂志(电子版),2018,14(1):99-103.
[21] Morris J,Bowen J,Patterson J,et al.Immediate delivery compared with expectant management after preterm pre-labour rupture of the membranes close to term[J].Lancet,2016,38710017(10017):1-9.
[22] Gupta S,Malik S,Gupta S.Neonatal complications in women with premature rupture of membranes (PROM) at term and near term and its correlation with time lapsed since PROM to delivery[J].Trop Doct,2019. doi: 10.1177/0049475519886447.
[23] Drassinower D,Friedman AM,Običan SG,et al.Prolonged latency of preterm premature rupture of membranes and risk of neonatal sepsis[J].Am J Obstet Gynecol,2016,2146(6):1-19.
[24] Hanke K,Hartz A,Manz M,et al.Preterm prelabor rupture of membranes and outcome of very-low-birth-weight infants in the German Neonatal Network[J].PLoS One,2015,104(4). doi:10.1371/journal.pone.0122564.
[25] Sim WH,Júnior EA,Costa FDS,et al.Maternal and neonatal outcomes following expectant management of preterm prelabour rupture of membranes before viability[J].J Perinat Med,2016,451(1):1-16.
[26] 韩彤妍,杨孜,朴梅花.绒毛膜羊膜炎与胎儿及新生儿疾病[J].中国实用妇科与产科杂志,2016,32(6):529-534.
[27] Strunk T,Doherty D,MBiostat AJ,et al.Histologic chorioamnionitis is associated with reduced risk of late-onset sepsis in preterm infants[J]. Pediatrics,2012,1291(1):134-133.
[28] Villamor-Martinez E,Lubach GA,Rahim OM,et al.Association of histological and clinical chorioamnionitis with neonatal sepsis among preterm infants: A systematic review, meta-analysis,and Meta-regression[J].Front Immunol,2020,11:1-19.
[29] Benitz WE,Wynn JL,Polin RA.Reappraisal of guidelines for management of neonates with suspected early-onset sepsis[J]. J Pediatr,2015,166(4):1070-1074.
[30] Polin RA,Watterberg K,Benitz W,et al.The conundrum of early-onset sepsis[J].Pediatrics,2014,133:1122-1123.
[31] Cantey JB,Pyle AK,Wozniak PS. et al.Early antibiotic exposure and adverse outcomes in preterm,very low birth weight infants[J].J Pediatr,2018,203:1-6.
[32] 陈潇,富建华.新生儿败血症229例临床特点、病原学分布及转归分析[J].中华实用儿科临床杂志,2019,34(10):740-744.
[33] 方广东,周勤姜,善雨,等.87例早产儿院内感染败血症的危险因素及病原学分析[J].中国儿童保健杂志,2018,26(2):208-211.
[34] Hassani SM,Berkhout DJC,Niemarkt HJ,et al.Risk factors for late-onset sepsis in preterm infants:A multicenter case-control study[J]. Neonatology,2019,116:42-51.
[35] Okada Y,Klein NJ,Saene HKF,et al.Bactericidal activity against coagulase-negative staphylococci is impaired in infants receiving long-term parenteral nutrition[J].Ann Surg,2000,231(2):276-281.
[36] 舒心宇,何昕晖,吴琪俊,等.未足月胎膜早破期待治疗后发生新生儿败血症独立危险因素分析[J].中国实用妇科与产科杂志,2018,34(12):1397-1400.