Objective To analyze the effect of transcranial direct current stimulation (tDCS) intervention on fine motor function in children with cerebral palsy, in order to provide theoretical reference for clinical application. Methods A total of 60 children with cerebral palsy aged 4 to 6 years were selected in the rehabilitation department of Chenzhou First People′s Hospital from June to December 2019, and were randomly divided into 2 groups. The control group (n=30) was treated with conventional rehabilitation, while the observation group (n=30) was given tDCS additionally. Both groups were treated for 6 weeks, with a frequency of 1 time/day, 5 days/week. The Peabody Fine Motor Development Scale (PDMS-FM) and Fine Motor Function Evaluation Scale (FMFM) were used to evaluate the changes of the two groups. Then the effect of intervention was compared. Results There was no significant difference in total effective rate between observation group and control group (92.9%vs.82.5%,χ2=0.74, P>0.05). However, difference in recovery rate between the two groups was found significant (67.9%vs.37.3%,χ2=5.24, P<0.01). After treatment, PDMS-FM scores of grasping, visual motor integration, fine motor quotient (t/t′=4.71, 2.54, 2.67) and each item in FMFM scale index (t/t′=4.35, 2.74, 3.31, 2.52, 2.15, 2.58) in observation group was significantly higher than those in control group (P<0.01 or <0.05). In both observation group and control group, PDMS-FM scale index (observation group t=16.67,23.13,6.59 and control group t=7.42, 14.81, 2.71) and each item in FMFM scale index (observation group t/t′=12.10, 13.51, 16.16, 12.62, 9.64, 14.28 and control group t/t′=8.46, 12.11, 9.26, 19.95, 12.97, 15.79) after treatment scored higher than that before treatment (P<0.01 or <0.05). Conclusion Both treatments can effectively improve fine motor function of children with cerebral palsy, but rehabilitation combined tDCS intervention therapy has a better overall efficacy than conventional rehabilitation therapy alone.
Key words
transcranial direct current stimulation /
cerebral palsy /
rehabilitation treatment /
fine motor
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References
[1] 徐艳,谢文龙,何凤翔.前馈控制结合躯干训练对小儿脑瘫患儿运动发育恢复及随访的影响[J].中国儿童保健杂志,2019,27(8):889-892.
[2] 贾飞勇.新生儿脑损伤的预后与康复[J].中国儿童保健杂志,2020,28(11):1185-1187,1192.
[3] 李晓捷,陈秀洁,姜志梅.实用小儿脑性瘫痪康复治疗技术[M].2版.北京:人民卫生出版社,2016:245.
[4] FlemingMK,Theologis T,Buckingham R,et al.Transcranial direct current stimulation for promoting motor function in cerebral palsy: a review[J].J Neuroeng Rehabil,2018,15(1):121-128.
[5] 唐久来,秦炯,邹丽萍,等.中国脑性瘫痪康复指南(2015):第一部分[J].中国康复医学杂志,2015,30(7):747-754.
[6] Bikson M,Paulus W,Esmaeilpour Z,et al.Mechanisms of acute and after effects of transcranial direct current stimulation[M]//knotkova H,Nitsche M,Bikson M,et al.Practical guide to Transcranial direct current stimulation.Cham:Springer,2019.
[7] KimYH.Noninvasive brain stimulation: repetitive transcranial magnetic stimulation and transcranial direct current stimulation[J].J Korean Med Assoc,2013,56(1):30-37.
[8] Minhas P,Bikson M,Woods AJ,et al.Transcranial direct current stimulation in pediatric brain:a computational modeling study[J].Conf Proc IEEE Eng Med Biol Soc, 2012,2012:859-862.
[9] 李明,黄真.Peabody运动发育量表[M].北京:北京大学医学出版社,2006:5-7.
[10] 徐东浩,史惟,李惠,等,脑瘫儿童精细运动功能测试量表的效度和反应度研究[J].中国康复医学杂志,2008,23(11):1010-1013.
[11] 赵德智. “补肾健脑针法”联合康复训练对痉挛型脑瘫患儿精细运动功能影响的临床研究[D].南京:南京中医药大学,2018.
[12] 张琼,高喜容.超低出生体重儿神经发育损伤的预防和预后研究进展[J].中国医师杂志,2016,18(1):148-150.
[13] DoyleLW,Clucas L,Roberts G,et al.The cost of long-term follow-up of high-risk infants for research studies[J].J Paediatr Child Health,2015,51(10):1012-1016.
[14] Stagg CJ,Nitsche MA.Physiological basis of transcranial di-rect current stimulation[J].Neuroscientist,2011,17(1):37-53.
[15] Carlsen AN,Eagles JS ,Mackinnon CD.Transcranial direct current stimulation over the supplementary motor area modulates the preparatory activation level in the human motor system[J].Behav Brain Res,2015,279:68-75.
[16] 池林.经颅直流电刺激对严重意识障碍患者的临床疗效研究[D].石家庄:河北医科大学,2017.
[17] 孔红涛,李三松.中药熏洗方联合小脑电刺激对脑瘫儿童的康复效果研究[J].陕西中医,2018,39(8):1098-1100,1104.
[18] Hordacre B,Moezzi B,Ridding MC.Neuroplasticity and network connectivity of the motor cortex following stroke: A transcranial direct current stimulation study[J].Hum Brain Mapp,2018,39(8):3326-3339.
[19] 张洪,刘静,杨未风,等.经颅直流电刺激联合常规言语康复治疗脑卒中后非流畅性失语症的疗效观察[J].康复学报,2017,27(3):39-42,46.