Objective To analyze the differences in clinical characteristics of twin premature infants between assisted reproductive technology (ART) conception and natural conception,in order to provide reference for perinatal healthcare. Methods A total of 2 900 twin premature infants delivered in 53 hospitals in 17 cities of Henan Province from January 1st,2019 to December 31st,2019 were selected as participants,and were divided into ART conception group (n=604) and natural conception group (n=2 296). The infants' general characteristics,complications,treatment and outcomes,as well as their mothers' perinatal conditions were compared and analyzed. Results The average age,the proportion of advanced age,the utilization rate of antenatal corticosteroid and cesarean section rate of the ART group were higher than those in the natural conception group (t=7.254,χ2=10.319,7.735,4.855,P<0.05). And the incidence rates of gestational hypertension and gestational diabetes in the ART group were significantly higher than those in the natural conception group (χ2=23.664,54.040,P＜0.01). The average gestational age of preterm infants in the ART group was lower than that in the natural conception group,and the ratio of gestational age less than 34 weeks and the asphyxia rate were higher than those in the natural conception group (t=-2.298,χ2=8.780,6.315,P＜0.05). But there were no significant differences in the main complications,treatment and outcomes between the two groups (P>0.05). Conclusions The maternal age,the proportion of advanced age,the incidence of gestational hypertension and gestational diabetes of the ART are higher than those of natural pregnancy. But ART does not increase the risk of short-term adverse outcomes for twin preterm infants. In view of the small gestational age and high suffocation rate of the twin preterm infants,the infants should be paid close attention during perinatal care and management.
Key words
preterm birth /
assisted reproductive technology /
twin pregnancy /
clinical outcomes
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