Research progress in the regulation of endocannabinoid system on abnormal neuroinflammation in autism spectrum disorder

XIE Shu, LIU Yu, LI De-xin, LI Ling, ZOU Ming-yang, SUN Cai-hong

Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (4) : 392-395.

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Chinese Journal of Child Health Care ›› 2022, Vol. 30 ›› Issue (4) : 392-395. DOI: 10.11852/zgetbjzz2020-1839
Review

Research progress in the regulation of endocannabinoid system on abnormal neuroinflammation in autism spectrum disorder

  • XIE Shu*, LIU Yu, LI De-xin, LI Ling, ZOU Ming-yang, SUN Cai-hong
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Abstract

Autism spectrum disorder (ASD) is a serious neurodevelopmental disorders with an increasing prevalence all over the world.Emerging evidence has implicated that neuroinflammation is one of the causes of ASD, including abnormal expression of inflammatory cytokines and abnormal activation of microglia.The endocannabinoid (eCB) system plays a key role in the regulation of the central nervous system, regulating the neuroinflammation and maintaining the immune balance.It has been confirmed that there is decreasing eCB signaling in ASD, and increasing eCB signaling can reduce the abnormal neuroinflammation of ASD and improve ASD symptoms.Therefore, inhibiting neuroinflammation by regulating the eCB system could be a new therapeutic target for ASD.This review combs the relationship and effect among the eCB system, neuroinflammation and ASD.

Key words

autism spectrum disorder / neuroinflammation / cytokines / microglia / endocannabinoid system

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XIE Shu, LIU Yu, LI De-xin, LI Ling, ZOU Ming-yang, SUN Cai-hong. Research progress in the regulation of endocannabinoid system on abnormal neuroinflammation in autism spectrum disorder[J]. Chinese Journal of Child Health Care. 2022, 30(4): 392-395 https://doi.org/10.11852/zgetbjzz2020-1839

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