Objective To explore the risk factors of childhood autism in early life,in order to provide reference for early prevention of autism. Methods A total of 100 children newly diagnosed with autism in a tertiary hospital in Hefei from June to September,2019,were enrolled in the case group.And 198 typical developed children were selected as the control group,matched by gender and age in 1∶2 case control study.Basic information of the family,mother′s situation during pregnancy and delivery period,and the children′s situation within 2 years after birth were investigated. Results Logistic regression analysis showed that marriage between blood relatives within three generations(OR=13.154,95%CI:2.225-77.785),epilepsy,mental retardation,dyskinesia or mental illness within three generations(OR=8.245,95%CI:2.165-31.394),maternal introversion personality(OR=3.263,95%CI:1.345-7.919),taking broad-spectrum antibiotics during pregnancy(OR=4.967,95%CI:1.344-18.362),premature(OR=3.698,95%CI:1.543-8.858)were risk factors for autism.Neonatal performance(compared with abnormal quiet,crying OR=0.275,95% CI:0.097-0.782),outdoor activity for at least 1 hour/day within 2 years old(1-2 hours/day OR=0.203,95%CI:0.050-0.828,＞2 hours/day OR=0.189,95%CI:0.048-0.747)were the protective factors of autism. Conclusions The occurrence of autism is affected by genetic factors,mother′s personality type,antibiotic use during pregnancy,premature delivery,neonatal performance and outdoor activity time within 2 years old.It is suggested to strengthen the early prevention and treatment of autism from the perspectives of these aspects.
Key words
autism /
early life /
children
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References
[1] 王广帅.自闭症谱系障碍儿童情绪社交缺陷量化评估与个性化干预[D].武汉:华中师范大学,2019.
[2] 杨淑涵,苏媛媛,韩钰,等.天津市孤独症谱系障碍儿童社区康复效果评价[J].中国学校卫生,2016,37(6):817-820.
[3] 段淑培.社区生命早期健康管理一体化模式构建[D].合肥:安徽医科大学,2020.
[4] Miguel PM,Pereira LO,Silveira PP,et al.Early environmental influences on the development of children′s brain structure and function[J].Dev Med Child Neurol,2019,61(10):1127-1133.
[5] 卜凡帅,徐胜.自闭症谱系障碍诊断标准:演变、影响与展望[J].中国特殊教育,2015,22(2):40-45.
[6] 毛萌,杨慧明.儿童早期发展的社会生物学意义[J].教育生物学杂志,2014,2(3):139-143.
[7] 张玉,刘芸,黄浩宇.孤独症病因学的研究进展[J].中国全科医学,2017,20(11):1392-1397.
[8] 刘智志,陆梅.孤独症谱系障碍相关风险基因与神经发育[J].中国实用儿科杂志,2019,34(7):594-598.
[9] 黄丽,李佳敏,朱华,等.通过外显子组测序对1例孤独症谱系障碍患者的致病基因分析[J].现代预防医学,2020,47(12):2242-2245.
[10] Lewis JD,Evans AC,Pruett JRJr,et al.The emergence of network inefficiencies in infants with autism spectrum disorder[J].Biol Psychiatry,2017,82(3):176-185.
[11] 吴晓丽,梁姗,王涛,等.肠道微生物与自闭症研究进展[J].科学通报,2018,63(18):1803-1821.
[12] Kovtun AS,Averina OV,Alekseeva MG,et al.Antibiotic resistance genes in the gut microbiota of children with autistic spectrum disorder as possible predictors of the disease[J].Microb Drug Resist,2020,26(11):1307-1320.
[13] 朱平,吴广霞,王永霞,等.孤独症谱系障碍的免疫学研究进展[J].中国免疫学杂志,2016,32(4):588-590,599.
[14] 赵锐豪,郑鹏远,刘思濛,等.孤独症谱系障碍儿童肠道菌群与行为症状的相关研究[J].中国当代儿科杂志,2019,21(7):663-669.
[15] 陆澄秋,林洁,黄金华,等.不同妊娠期并发症/合并症对胎龄小于34周早产儿结局的影响[J].复旦学报(医学版),2020,47(2):251-256.
[16] Talmi Z,Mankuta D,Raz R.Birth weight and autism spectrum disorder:a population-based nested case-control study[J].Autism Res,2020,13(4):655-665.
[17] 马居飞,匡桂芳,曲烨,等.孤独症谱系障碍儿童父母性格特征和家庭环境的病例对照研究[J].中国学校卫生,2015,36(6):861-863.
[18] 陈素香.人性化护理干预对提升新生儿舒适度的影响分析[J].中国临床护理,2016,8(2):140-142.
[19] Gillderg C.Autism and related behaviours[J].J Intellect Disabil Res,1993,37(4):343-347.
[20] 马伟娜,朱蓓蓓.孤独症儿童的情绪共情能力及情绪表情注意方式[J].心理学报,2014,46(4):528-539.
[21] 王瑜,陈连红,张凤玲.儿童自闭症101例的高危因素配对分析[J].中国儿童保健杂志,2014,22(6):597-599.
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