Objective To analyze the effect of breastfeeding quality improvement on in very/extremely low birth weight infants, so as to provide effective measures for clinicians. Methods Totally 160 very/extremely low birth weight infants admitted in Wuxi Maternity and Child Health Care Hospital during January 2018 to December 2019 were analyzed. Newborns admitted in 2018 were selected into the control group, while those admitted in 2019 were enrolled in the intervention group receiving breastfeeding quality improvement measures. Feeding indexes were compared between the two groups. Results The onset time for pumping milk, fasting times, fasting days and intravenous nutrition time in intervention group were shorter than those in control group(t=2.007, 2.666, 2.222, 3.187, P＜0.05). But there were no significant differences in the lactation start time, the average daily number of milk pumps, the first breastfeeding time, the amount of mother's breast milk during hospitalization, the starting time of feeding, the duration of micro feeding, and the time for reaching full enteral feeding between the two groups(P>0.05). The rates of feeding intolerance and bronchopulmonary dysplasia in the intervention group were significantly higher than that in control group (χ²=4.368, 3.963, P＜0.05), but the differences were not significant on the rates of neonatal necrotizing enterocolitis, sepsis and neonatal cholestasis syndrome(P>0.05). Conclusion The improvement of breastfeeding quality can shorten the time of starting to pump milk and intravenous nutrition, reduce the times and days of fasting, reduce the incidence of feeding intolerance and bronchopulmonary dysplasia, which can provide effective measures for clinicians to treat very/extremely low birth weight infants.