Application of different doses of vitamin D supplementation in premature infants

LIU Yi-rong; ZENG Chun-ying; ZHANG Wen-jing; LIU Dong; CAI Yue-ju

doi:10.11852/zgetbjzz2020-1807

PDF(365 KB)

Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (10) : 1142-1144. DOI: 10.11852/zgetbjzz2020-1807

Clinical Research

Application of different doses of vitamin D supplementation in premature infants

LIU Yi-rong^*, ZENG Chun-ying, ZHANG Wen-jing, LIU Dong, CAI Yue-ju

Author information +

History +

Abstract

Objective To evaluate the effect of different doses of vitamin D supplementation on vitamin D level of preterm infants with gestational age ≤34 weeks at discharge,in order to provide evidence for the post-natal vitamin supplementation of premature infants. Methods A total of 67 premature infants with gestational age 34 weeks or less in Boluo Maternal and Child Care Hospital from January 2019 and June 2020 were randomly divided into low-dose group(32 cases) and high-dose group(n=35) after full enteral feeding. Then the discharge level of 25(OH)D,vitamin D insufficiency and related adverse reactions were compared. Results There was no statistically significant difference in the level of 25 (OH) D of umbilical cord blood at birth between low-dose group and high-dose group (P>0.05). The serum 25 (OH) D level of infants in the high-dose group was significantly higher than that of the low-dose group(t=2.872,P＜0.05). The incidence of vitamin D deficiency/insufficiency at discharge in the high-dose group was significantly lower than that in the low-dose group (χ²=4.189,P＜0.05). However,the incidence of vitamin D deficiency/deficiency in the high-dose group still reached to 28.6%. Conclusions For premature infants with gestational age ≤34 weeks,supplementing vitamin D at 800 U/d can significantly improve the deficiency or insufficiency of vitamin D at discharge. However,for ultra-low birthweight infants with lower gestational age and lower birth weight,a larger dose of vitamin D supplementation may be required.

Key words

vitamin D / vitamin D deficiency/insufficiency / premature infants

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

LIU Yi-rong, ZENG Chun-ying, ZHANG Wen-jing, LIU Dong, CAI Yue-ju. Application of different doses of vitamin D supplementation in premature infants[J]. Chinese Journal of Child Health Care. 2021, 29(10): 1142-1144 https://doi.org/10.11852/zgetbjzz2020-1807

References

[1] Fettah ND,Zenciroğlu A,Dilli SD,et al.Is higher 25-hydroxyvitamin D level preventive for respiratory distress syndrome in preterm infants?[J].Am J Perinatol,2015,32 (3): 247-250.
[2] Lykkedegn S,Sorensen GL,Beck-Nielsen SS,et al.The impact of vitamin D on fetal and neonatal lung maturation:a systematic review[J].Am J Physiol Lung Cell Mol Physiol,2015,308(7):587-602.
[3] Cetinkaya M,Erener-Ercan T,Kalayci-Oral T,et al.Maternal/neonatal vitamin D deficiency: a new risk factor for necrotizing enterocolitis in preterm infants?[J].J Perinatol,2017,37(6):673-678.
[4] Ozdemir AA,Cag Y.Neonatal vitamin D status and the risk of neonatal sepsis[J].Pak J Med Sci,2019,35(2):420-425.
[5] Saraf R,Morton SM,Camargo CA,et al.Global summary of maternal and newborn vitamin D status-a systematic review[J].Matern Child Nutr,2016,12(4): 647-668.
[6] Calton EK,Keane KN,Newsholme P,et al.The impact of vitamin D levels on inflammatory status: a systematic review of immune cell studies[J].PLoS One,2015,10 (11): e0141770.
[7] Clancy N,Onwuneme C,Carroll A,et al.Vitamin D and neonatal immune function[J].J Matern Fetal Neonatal Med,2013,26(7):639-646.
[8] Matejek T,Navratilova M,Zaloudkova L,et al.Vitamin D status of very low birth weight infants at birth and the effects of generally recommended supplementation on their vitamin D levels at discharge[J].J Matern Fetal Neonatal Med,2020,33 (22):3784-3790.
[9] SŠrensen IM,Joner G,Jenum PA,et al.Maternal serum levels of 25-hydroxy-vitamin D during pregnancy and risk of type 1 diabetes in the offspring[J] . Diabetes,2012,61(1):175-178.
[10] Mensink-Bout SM,van-Meel ER,de-Jongste JC,et al.Maternal and neonatal 25-hydroxyvitamin D concentrations and school-age lung function,asthma and allergy.The Generation R Study[J].Clin Exp Allergy,2019,49(6):900-910.
[11] Panda M,McIntosh J,Chaudhari T,et al.Do maternal vitamin D levels influence vitamin D levels in preterm neonates?[J].Int J Pediatr,2019. doi: 10.1155/2019/8613414
[12] Sotunde OF,Laliberte A,Weiler HA,et al.Maternal risk factors and newborn infant vitamin D status: a scoping literature review[J].Nutr Res,2019,63:1-20.
[13] Matejek T,Zemankova J,Malakova J,et al.Severe vitamin D deficiency in preterm infants: possibly no association with clinical outcomes?[J].J Matern Fetal Neonatal Med,2020,1:1-9.
[14] Munshi UK,Graziano PD,Meunier K,et al.Serum 25 hydroxy vitamin D levels in very low birth weight infants receiving oral vitamin D supplementation[J].J Pediatr Gastroenterol Nutr,2018,66(4):676-679.