Objective To investigate the relationship between serum 25 hydroxy vitamin D [25(OH) D] level and respiratory distress syndrome (RDS) in preterm infants,in order to provide new ideas for clinical prevention of RDS. Methods A total of 179 preterm infants admitted to NICU, Obstetrics and Gynecology Hospital Affiliated to Fudan University from March 2018 to May 2020 were included in the analysis.Cord blood was collected at birth, and the serum 25(OH)D level in cord blood was determined by chemiluminescent microparticle immunoassay.The infants were divided into RDS group and control group according to the diagnosis of RDS.According to whether serum 25(OH)D level was lower than 20 ng/ml, the infants were divided into vitamin D reduction group and normal group.The differences on the influencing factors between the two groups were analyzed and compared. Results Among all preterm infants, 25.1% were deficient in 25(OH)D level (<10 ng /ml), 42.5% were deficient (10—<20 ng/ml), and 32.4% were normal (≥20 ng/ml).The level of 25(OH)D in cord blood of RDS group [(11.3±7.2) ng/ml] was significantly lower than that of the control group [(15.88±8.4) nmol/L, t=3.469, P<0.01)].The prevalence of 25(OH)D decrease in RDS group was 89.0% (121/136), which was significantly higher than that in control group [46.5% (20/43), χ2= 35.221, P <0.01)].Multivariate analysis result indicated that gestational age and decreasing serum 25(OH)D level in cord blood were independent risk factors for RDS in preterm infants(OR=39.694, 5.696, P＜0.05). Conclusion The prevalence of vitamin D deficiency in preterm infants is high, and it may increase the incidences of RDS.
Key words
25 hydroxy vitamin D /
respiratory distress syndrome /
risk factors /
infant, preterm infants
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