Objective To investigate the effect of overweight and obesity on tidal lung function of infants with recurrent wheezing,in order to provide evidence for the prevention and control of asthma. Methods A total of 100 children aged 0 to 3 years with recurrent wheezing were selected in this study from Child Respiratory Department in Guangdong Women and Children Hospital. According to body mass index (BMI),wheezing children were divided into non-overweight group (n=70) and overweight/obesity group (n=30). And 80 children aged 0 to 3 years without respiratory diseases were selected as control group and divided into non-overweight group (n=50) and overweight/obesity group(n=30) according to BMI. The tidal breathing parameters and flow-volume loop of infants in each group were recorded and compared. Results The values oftime to peak tidal expiratory flow as a proportion of expiratory time(TPTEF/TE),volume to peak expiratory flow as a proportion of exhaled volume(VPTEF/VE),inspiratory time/expiratory time(TI∶TE),tidal expiratory flow when 25% of tidal volune remain in the lung/peak tidal expiratory flow(25/PF) of the wheezing infants with non-overweight significantly decreased compared with the control group without wheezing (t=8.518,7.767,3.142,7.860,P<0.05),while peak tidal expiratory flow(PTEF),tidal expiratory flow when 75% of tidal volume remains in the lung(TEF75) increased (t=6.728,8.540,P<0.05). In the control group and the wheezing group,compared with the non-overweight infants,tidal volume/kg(VT/kg) of infants with overweight and obesity decreased (t=2.872,3.048,P<0.05). Conclusion Overweight and obesity have impacts on VT/kg of tidal lung function,but did not affect airway obstruction indicators.
Key words
overweight and obesity /
tidal lung function /
recurrent wheezing /
infants
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