Objective To explore the association between platelet parameters at birth and the risk of moderate/severe bronchopulmonary dysplasia (BPD) in a cohort of extremely preterm infants. Methods The data of premature infants with gestational age ≤28 weeks and birth weight<1 500 g admitted to the Neonatal Intensive Care Unit, Dalian Maternal and Child Health Care Hospital of Dalian Medical University from September 2014 to December 2019 were retrospectively collected.The preterm infants were divided into non-BPD, mild BPD and moderate/severe BPD groups.The differences in platelet parameters in 24 hours after birth among the three groups were compared, including platelet count (PLT), mean platelet volume (MPV), platelet distribution width (PDW) and platelet mass.Receiver operating characteristic (ROC) curve was used to evaluate the early predictive value of platelet parameters for moderate/severe BPD. Results A total of 147 premature infants were enrolled, including 71 non-BPD infants,35 mild BPD infants and 41 infants with moderate/severe BPD.The value of MPV in 24 hours after birth was significantly higher in moderate/severe BPD group than that in non-BPD group and mild BPD group(F=8.048,P<0.001).But there were no significant differences in PLT, PDW and platelet mass among the three groups (P>0.05).Multivariate Logistic regression analysis indicated that with the increase of gestational age, the risk of moderate/severe BPD decreased (OR=0.466, 95%CI:0.247-0.880).The increasing MPV(OR=2.522, 95%CI:1.313-4.847), higher number of blood transfusions(OR=2.177, 95%CI:1.135-4.177), and longer duration of mechanical ventilation(OR=3.296, 95%CI:1.071-10.144).ROC curve analysis showed that the best diagnostic cut-off value of MPV was 10.55 fl,and the sensitivity and specificity of early prediction of moderate/severe BPD was about 62.2% and 76.8%, respectively. Conclusions A higher level of MPV in the first 24 hours of life may increase the risk of moderate/severe BPD after extremely premature birth.The change of MPV is likely to be related to the onset of BPD in preterm infants.
Key words
bronchopulmonary dysplasia /
blood platelet /
mean platelet volume /
preterm infants
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