Objective To investigate the diagnostic value of serum leptin,omentin-1 and adiponectin in girls with idiopathic central precocious puberty (ICPP),in order to provide evidence for the clinical application. Methods From April 2017 to August 2019,124 girls with ICPP,86 girls with premature thelarche (PT) and 100 healthy girls were selected as the study objects. The levels of serum leptin,omentin-1 and adiponectin were tested by enzyme-linked immunosorbent assay. ROC curve was used to analyze the value of each index in diagnosis and differential diagnosis,and AUC was calculated. Results Compared with the control group,the level of leptin was higher,omentin-1 and adiponectin were lower in ICPP group (P<0.05). Leptin level was higher and omentin-1 level was lower in PT group than that in control group (P<0.05). Compared with PT group,the level of leptin was higher and omentin-1 was lower in ICPP group (P<0.05). The AUC of leptin,omentin-1 and adiponectin in the diagnosis of ICPP was 0.898,0.842 and 0.799,respectively. The combined detection of the three indicators increased AUC to 0.920. The AUC of leptin,omentin-1 and adiponectin in the differential diagnosis of ICPP and PT were 0.761,0.604 and 0.572,respectively. The combined detection of the three indicators increased AUC to 0.775. Conclusion Serum adipokine leptin,adiponectin and omentum-1 have certain clinical value in the diagnosis of ICPP and the differential diagnosis between ICPP and PT.
Key words
leptin /
omentin-1 /
adiponectin /
premature thelarche /
idiopathic central precocious puberty
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