Meta-analysis of the effect of pulmonary ureaplasma urealyticum infection on bronchopulmonary dysplasia

LI He-jia; HAO Ling; MIAO Jia-li; HUANG Jia-yu; MENG Jin-feng; REN Chang-jun

doi:10.11852/zgetbjzz2020-1298

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (12) : 1333-1338. DOI: 10.11852/zgetbjzz2020-1298

Meta Analysis

Meta-analysis of the effect of pulmonary ureaplasma urealyticum infection on bronchopulmonary dysplasia

LI He-jia, HAO Ling, MIAO Jia-li, HUANG Jia-yu, MENG Jin-feng, REN Chang-jun

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Abstract

Objective To analyze the effect of pulmonary ureaplasma urealyticum (UU) infection on bronchopulmonary dysplasia (BPD), so as to provide evidence for preventing BPD in preterm infants. Methods Eight databases including PubMed, EMBASE, Web of Science, Cochrane Library, CNKI, Wanfang Data, VIP and China Biomedical Database (CBM) were searched to collect the cohort study on the effect of pulmonary UU infection on BPD, and the source of samples were endotracheal. The retrieval time was from the establishment of the database to April 15th, 2020. Meta-analysis was carried out by using stata 15.1 software. Results A total of 21 cohort studies were included, 18 of which assessed outcomes at the 28th days after birth, 9 of which assessed outcomes at the 36th weeks of adjusted gestational age. Totally 3 039 subjects were included, 831 of whom were in UU infection group and 2 085 were in UU non-infection group. Random effect model indicated that UU infection did not increase the risk of BPD (assessment on the 28^th days after birth RR=1.69, 95%CI: 1.42 - 2.01; assessment on the adjusted gestational age of 36 weeks RR=1.20, 95%CI: 0.91 - 1.58). Conclusions Based on the existing research data, it can not be determined that UU infection is the influencing factor of BPD. A unified diagnostic standard of BPD and higher quality cohort studies are warranted to explore the relationship between UU infection and BPD.

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ureaplasma urealyticum / bronchopulmonary dysplasia / neonatal chronic lung disease / Meta-analysis

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LI He-jia, HAO Ling, MIAO Jia-li, HUANG Jia-yu, MENG Jin-feng, REN Chang-jun. Meta-analysis of the effect of pulmonary ureaplasma urealyticum infection on bronchopulmonary dysplasia[J]. Chinese Journal of Child Health Care. 2021, 29(12): 1333-1338 https://doi.org/10.11852/zgetbjzz2020-1298

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