Objective To explore the feasibility of early intervention using the general movements (GMs) assessment results as grouping guidance in very premature and extremely premature infants,in order to provide basis for clinic application. Methods From May 2016 to May 2019, 76 premature infants (51 very premature infants and 25 extremely premature infants) who received early intervention in the rehabilitation department of Xiamen Children's Hospital were enrolled in the study. Regular follow-up protocol was conducted to these infants. The gross motor developmental outcome was evaluated at corrected age of 12 months old. Results According to GMs results, 76 premature infants were divided into group A (high risk), group B (medium risk) and group C (low risk) for early intervention till corrected age of 12 months old. Altogether 16 cases (21.1%) had abnormal motor development outcomes, among whom there were 11 cases (14.5%) with cerebral palsy and 5 cases (6.6%) with motor development retardation. Conclusion It is feasible to apply GMs results to guide early intervention in grouping of very early and extremely premature infants, so as to reasonably allocate rehabilitation medical resources, indicating that GMs assessment can be further applied in clinical work.