Objective To study the relationship between Toll like receptor (TLRs) signaling pathway and expression of inflammatory factors and recurrent respiratory tract infection, in order to provide monitoring targets for clinical treatment. Methods A total of 150 children with recurrent respiratory tract infection treated in the Second People's Hospital of Longhu District from January to December 2019 were included in this study and were selected as case group. Meanwhile, 150 healthy children who took physical examination were selected as control group. Then the levels of TLRs signaling pathway, inflammatory related factors and oxidative stress related indexes were compared between the two groups. Results The levels of Toll like receptor 2 (TLR2) and TLR4 in the case group were significantly higher than those in the control group(t=69.981, 101.427, P＜0.001). Additionally, the levels of serum interleukin-4 (IL-4),interleukin-10(IL-10) and interferon gamma (INF-γ) in the case group were significantly higher than those in control group(t=78.453, 63.388, 116.697, P＜0.001), while the level of tumor necrosis factor-α (TNF-α) was significantly lower in the case group(t=70.489, P＜0.001). Pearson correlation analysis showed that the TLR2 and TLR4 levels were positively related to the levels of IL-4, IL-10 and TNF-α, but negatively correlated with INF-γ levels(P＜0.05). The differences on superoxide dismutase(SOD), malondialdehyde(MDA) and catalase(CAT) between the case group and control group were significant(t=28.633, 57.277, 50.103, P＜0.001). Conclusion The TLRs signaling pathway and inflammatory factors may be involved in the occurrence and development of recurrent respiratory tract infection, and children with recurrent respiratory tract infection apparently have abnormal oxidative stress.
Key words
recurrent respiratory tract infection /
Toll like receptor signaling pathway /
inflammatory factors /
oxidative stress response
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