Progress on the understanding the involvement of exercise in epigenetic regulation of early childhood development

ZHANG Ting

doi:10.11852/zgetbjzz2020-0876

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (6) : 605-608. DOI: 10.11852/zgetbjzz2020-0876

Progress on the understanding the involvement of exercise in epigenetic regulation of early childhood development

ZHANG Ting

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Abstract

During early childhood development,the dynamic programming of epigenetics is closely correlated with the dietary balance of infants and young children,but also closely related to children′s physical movement.Diet and physical movement jointly affect the upstream metabolic balance of epigenetic modification,which fully reflects the interaction between genetics and the internal environment during the development of children.To this end,this article introduces the effect of physical activities on the body′s epigenetic modification and even the regulation of downstream functional genes,with emphasis on the progress on epigenetics mechanism from three different levels:the participation of movement in DNA methylation,chromosomal histone modification and miRNA regulation,thereby providing a more systematic epigenetic basis for physical movement′s needs in early childhood development,especially for parent-child exercise in early childhood development.

Key words

physical activities / epigenetics / early childhood development

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ZHANG Ting. Progress on the understanding the involvement of exercise in epigenetic regulation of early childhood development[J]. Chinese Journal of Child Health Care. 2020, 28(6): 605-608 https://doi.org/10.11852/zgetbjzz2020-0876

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