Objective To analyze the effects of family-based early environmental enrichment rehabilitation on Gross Motor Function Measure Scale(GMFM) and daily activity(ADL) for 0- to 6-month-old infants at high risk of cerebral palsy. Methods A total of 124 infants at higher risk for cerebral palsy who were followed up in Taizhou Women and Children′s Hospital from August 2015 to August 2018 were enrolled in this study, and were randomly divided into the control group and treatment group.The control group was given routine rehabilitation training, while the treatment group was given family-based early environmental enrichment rehabilitation guidance additionally, such as visual, auditory, tactile intervention and family posture management.GMFM and ADL scores of the two groups were evaluated in the first visit, 3 months and 6 months of intervention, respectively. Results There were no significant differences in age, gender, GMFM score and ADL score between the two groups at the time of initial diagnosis(P>0.05).After 3 months of intervention, the GMFM score(t=5.594, P<0.001) and ADL score(t=9.793, P<0.001) of the treatment group were higher than those of the control group.After 6 months of intervention, GMFM score(t=8.829, P<0.001) and ADL score(t=11.469, P<0.001) in the treatment group were higher than those in the control group.After 3 months of intervention, there was no significant difference in the total effective rate between the two groups(P>0.05).But the total effective rate of intervention group was significantly higher than that of control group after 6-month intervention(98.4% vs.80.6%, P<0.05). Conclusion Family-based early environmental enrichment rehabilitation is conducive to improving gross motor function and daily living ability of infants at high risk of cerebral palsy, and significantly improving the prognosis of high-risk infants with cerebral palsy.