Epidemiological and clinical characteristics analysis of adenovirus infection in 9 962 hospitalized children with acute respiratory tract infection

LI Quan-heng; HAO Xiao-jing; DONG Wei-ran; GAO Wen-jie; WANG Yan-yan; ZHANG Lei; LI Qing-tao; LIU Xiao-juan; ZHANG Li-jun; LI Jin-ying; AN Shu-hua; WANG Le

doi:10.11852/zgetbjzz2020-0585

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (12) : 1412-1415. DOI: 10.11852/zgetbjzz2020-0585

Epidemiological and clinical characteristics analysis of adenovirus infection in 9 962 hospitalized children with acute respiratory tract infection

LI Quan-heng¹, HAO Xiao-jing², DONG Wei-ran³, GAO Wen-jie³, WANG Yan-yan³, ZHANG Lei³, LI Qing-tao³, LIU Xiao-juan⁴, ZHANG Li-jun³, LI Jin-ying⁵, AN Shu-hua³, WANG Le⁶

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Abstract

Objective To describe the characteristics of adenovirus infection in children with acute respiratory infection, so as to provide reference for the treatment and prevention of acute respiratory infection in children. Methods From December 2016 to December 2018, a total of 9 962 children with acute respiratory infection in Hebei Children′s Hospital were enrolled in this study.The pathogens including adenovirus were detected by RT-PCR in children′s nasopharyngeal secretions, and the detection rate and clinical characteristics of adenovirus were analyzed. Results The total detection rate of adenovirus was 4.78%(176/9 962), and there was no significant difference between male and female(P＞0.05).There was significant difference in detection rate among different age groups(χ²=160.042, P<0.001).The highest detection rate in 2016—2018 was in November.There was no significant difference in the composition ratio of adenovirus infection during the two years(P>0.05), and bronchopneumonia was the major diagnosis.The total mixed infection rate of respiratory tract infection caused by adenovirus was 61.76%(294/476), and there was a significant difference in the mixed infection rate of each diagnosis(χ²=31.398, P<0.001). Conclusions Adenovirus is a common pathogen of respiratory tract infection in children in local area of Hebei, with a peak in November, causing symptoms of whole respiratory tract.Bronchopneumonia is the first diagnosis in all age groups.Adenovirus infections have a high rate of co-infection, with a rising trend of co-infection as respiratory infections spread downward.

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acute respiratory tract infection / adenovirus / hospitalization / epidemiology

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LI Quan-heng, HAO Xiao-jing, DONG Wei-ran, GAO Wen-jie, WANG Yan-yan, ZHANG Lei, LI Qing-tao, LIU Xiao-juan, ZHANG Li-jun, LI Jin-ying, AN Shu-hua, WANG Le. Epidemiological and clinical characteristics analysis of adenovirus infection in 9 962 hospitalized children with acute respiratory tract infection[J]. Chinese Journal of Child Health Care. 2020, 28(12): 1412-1415 https://doi.org/10.11852/zgetbjzz2020-0585

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