Objective To investigate the detection rate of gastrointestinal symptoms,and to analyze the association between gastrointestinal symptoms and behavioral manifestations in children with autism spectrum disorder(ASD),so as to provide new ideas for the intervention of ASD. Methods A total of 112 ASD children diagnosed according to the fifth edition of Diagnostic and Statistical Manual for Mental Disorders and 100 normal controls in the Department of Pediatrics of the Affiliated Hospital of Jiangsu University were enrolled in this study from January 2017 to December 2019.Childhood Autism Rating Scale (CARS) and Autism Behavior Checklist (ABC) were used to assess the symptoms of autistic children,Gesell Development Scale (GDS) was used to evaluate the development of autistic children,and questionnaire was used to investigate the occurrence of gastrointestinal symptoms and behavior performance in children. Results The detection rate of gastrointestinal symptoms in ASD group was significantly higher than that in control group (72.3% vs.24.0%,χ2=33.012,P<0.001).ASD children were divided into the gastrointestinal symptoms group (n=62) and the gastrointestinal symptoms-free group (n=50).The differences of GDS,CARS and ABC between the two groups were not statistically significant (P>0.05).However,the score of emotional problems,behavioral problems,stereotypies or repetitive behaviors and the overall score in the gastrointestinal symptoms group were significantly higher than those in gastrointestinal symptoms-free group (t=4.868,4.101,4.812,5.968,P＜0.001). Conclusions The prevalence of gastrointestinal symptoms in ASD children is significantly higher than that in typical children.ASD children with gastrointestinal symptoms have more serious emotional and behavioral problems than children without gastrointestinal symptoms,indicating that clinical intervention of gastrointestinal symptoms may be of great significance to the rehabilitation of ASD children.
Key words
autism spectrum disorder /
gastrointestinal symptoms /
behavioral manifestations /
children
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