Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children

YANG Xiao-yan; HOU Cheng; YI Ming-ji

doi:10.11852/zgetbjzz2020-0353

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (8) : 857-860. DOI: 10.11852/zgetbjzz2020-0353

Review

Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children

YANG Xiao-yan, HOU Cheng, YI Ming-ji

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Abstract

Besides being a nutrient and a hormone,vitamin D is a neuroactive steroid.In addition to regulating calcium and phosphorus metabolism,as well as maintaining the health of teeth and bones,vitamin D has been shown to play several important roles in extra-skeletal system,such as affecting the normal development and function of the brain,regulating immunity and affecting metabolism.In recent years,some researches have shown that serum vitamin D level in children with tic disorders (TDs) was lower than that of the healthy controls.The mechanism of vitamin D deficiency on TDs in children may involve the following aspects,changing neurotransmitter concentration and disrupting the balance between various neurotransmitters in the CBGTC pathway and effecting body's immune function.This review aims to summarize the nutritional status of vitamin D in children with TDs and the neurobiochemical and immunological mechanisms of vitamin D in TDs.

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vitamin D / tic disorders / neurodevelopment / immune function

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YANG Xiao-yan, HOU Cheng, YI Ming-ji. Research progress on the neurobiochemical and immunological mechanism of vitamin D in tic disorders of children[J]. Chinese Journal of Child Health Care. 2021, 29(8): 857-860 https://doi.org/10.11852/zgetbjzz2020-0353

References

[1] Gloor FT,Walitza S.Tic disorders and Tourette syndrome:Current concepts of etiology and treatment in children and adolescents[J].Neuropediatrics,2016,47(2):84-96.
[2] Dhamayanti M,Noviandhari A,Supriadi S,et al.Association of maternal vitamin D deficiency and infants' neurodevelopmental status:A cohort study on vitamin D and its impact during pregnancy and childhood in Indonesia[J].J Paediatr Child Health,2020,56(1):16-21.
[3] Schmidt RJ,Niu Q,Eyles DW,et al.Neonatal vitamin D status in relation to autism spectrum disorder and developmental delay in the CHARGE case-control study[J].Autism Res,2019,12(6):976-988.
[4] Bscheider M,Butcher EC.Vitamin D immunoregulation through dendritic cells[J].Immunology,2016,148(3):227-236.
[5] Feng J,Shan L,Du L,et al.Clinical improvement following vitamin D₃ supplementation in autism spectrum disorder[J].Nutr Neurosci,2017,20(5):284-290.
[6] Dehbokri N,Noorazar G,Ghaffari A,et al.Effect of vitamin D treatment in children with attention-deficit hyperactivity disorder[J].World J Pediatr,2019,15(1):78-84.
[7] 李洪华,王冰,单玲,等.抽动障碍患儿血清25羟基维生素D水平的检测[J].中国当代儿科杂志,2017,19(11):1165-1168.
[8] 陈先睿,黄建琪,陈玲,等.血清25羟维生素D水平在抽动障碍儿童中的临床研究[J].中国妇幼保健,2019,34(18):4228-4231.
[9] Li HH,Shan L,Wang B,et al.Serum 25-hyroxyvitamin D levels and tic severity in Chinese children with tic disorders[J].Psychiatry Res,2018,267:80-84.
[10] Mossin MH,Aaby JB,Dalgård C,et al.Inverse associations between cord vitamin D and attention deficit hyperactivity disorder symptoms:A child cohort study[J].Aust NZJ Psychiatry,2017,51(7):703-710.
[11] Windham GC,Pearl M,Anderson MC,et al.Newborn vitamin D levels in relation to autism spectrum disorders and intellectual disability:A case-control study in california[J].Autism Res,2019,12(6):989-998.
[12] Li HH,Xu ZD,Wang B,et al.Clinical improvement following vitamin D3 supplementation in children with chronic tic disorders[J].Neuropsychiatr Dis Treat,2019,15:2443-2450.
[13] 崔圣涛.小儿抽动症与微量元素及维生素A/D/E的相关性研究[D].吉林:长春中医药大学,2017.
[14] Hienert M,Gryglewski G,Stamenkovic M,et al.Striatal dopaminergic alterations in Tourette's syndrome:a meta-analysis based on 16 PET and SPECT neuroimaging studies[J].Transl Psychiatry,2018,8(1):143.
[15] Augustine F,Singer HS.Merging the pathophysiology and pharmacotherapy of Tics[J].Tremor Other Hyperkinet Mov (NY),2018,8:595.
[16] Nespoli E,Rizzo F,Boeckers T,et al.Altered dopaminergic regulation of the dorsal striatum is able to induce tic-like movements in juvenile rats[J].PLoS One,2018,13(4):e0196515.
[17] Luan W,Hammond LA,Cotter E,et al.Developmental vitamin D (DVD) deficiency reduces nurr1 and TH expression in post-mitotic dopamine neurons in rat mesencephalon[J].Mol Neurobiol,2018,55(3):2443-2453.
[18] Pertile R,Cui X,Hammond L,et al.Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons[J].FASEB J,2018,32(2):819-828.
[19] McCairn KW,Nagai Y,Hori Y,et al.A primary role for nucleus accumbens and related limbic network in vocal Tics[J].Neuron,2016,89(2):300-307.
[20] Sikoglu EM,Navarro AA,Starr D,et al.Vitamin D3 supplemental treatment for mania in youth with bipolar spectrum disorders[J].J Child Adolesc Psychopharmacol,2015,25(5):415-424.
[21] Kasatkina LA,Tarasenko AS,Krupko OO,et al.Vitamin D deficiency induces the excitation/inhibition brain imbalance and the proinflammatory shift[J].Int J Biochem Cell Biol,2020,119:105665.
[22] Jiang P,Zhang LH,Cai HL,et al.Neurochemical effects of chronic administration of calcitriol in rats[J].Nutrients,2014,6(12):6048-6059.
[23] Krisanova N,Pozdnyakova N,Pastukhov A,et al.Vitamin D₃ deficiency in puberty rats causes presynaptic malfunctioning through alterations in exocytotic release and uptake of glutamate/GABA and expression of EAAC-1/GAT-3 transporters[J].Food Chem Toxicol,2019,123:142-150.
[24] Müller-Vahl KR,Szejko N,Wilke F,et al.Serotonin transporter binding is increased in Tourette syndrome with obsessive compulsive disorder[J].Sci Rep,2019,9(1):972.
[25] Xu M,Kobets A,Du JC,et al.Targeted ablation of cholinergic interneurons in the dorsolateral striatum produces behavioral manifestations of Tourette syndrome[J].Proc Natl Acad Sci USA,2015,112(3):893-898.
[26] Pichler EM,Kawohl W,Seifritz E,et al.Pure delta-9-tetrahydrocannabinol and its combination with cannabidiol in treatment-resistant Tourette syndrome:A case report[J].Int J Psychiatry Med,2019,54(2):150-156.
[27] Andrews PW,Bharwani A,Lee KR,et al.Is serotonin an upper or a downer? The evolution of the serotonergic system and its role in depression and the antidepressant response[J].Neurosci Biobehav Rev,2015,51:164-188.
[28] Medhat E,Rashed L,Abdelgwad M,et al.Exercise enhances the effectiveness of vitamin D therapy in rats with Alzheimer's disease:emphasis on oxidative stress and inflammation[J].Metab Brain Dis,2020,35(1):111-120.
[29] Di Marzo V,Silvestri C.Lifestyle and metabolic syndrome:contribution of the endocannabinoidome[J].Nutrients,2019,11(8).pii:E1956.
[30] Spinello C,Laviola G,Macrì S.Pediatric autoimmune disorders associated with streptococcal infections and Tourette's syndrome in preclinical studies[J].Front Neurosci,2016,10:310.
[31] 侯晓君,林珊,林祥泉,等.抽动障碍儿童Th淋巴细胞及其亚群的变化[J].中国当代儿科杂志,2018,20(7):519-523.
[32] Dileepan T,Smith ED,Knowland D,et al.Group A Streptococcus intranasal infection promotes CNS infiltration by streptococcal-specific Th17 cells[J].J Clin Invest,2016,126(1):303-317.
[33] Frick L,Pittenger C.Microglial Dysregulation in OCD,Tourette syndrome,and PANDAS[J].J Immunol Res,2016,2:1-8.
[34] Lennington JB,Coppola G,Kataoka-Sasaki Y,et al.Transcriptome analysis of the human striatum in Tourette syndrome[J].Biol Psychiatry,2016,79(5):372-382.
[35] Szymczak I,Pawliczak R.The active metabolite of vitamin D₃ as a potential immunomodulator[J].Scand J Immunol,2016,83(2):83-91.
[36] Verma R,Kim JY.1,25-Dihydroxyvitamin D₃ facilitates M2 polarization and upregulates TLR10 expression on human microglial cells[J].Neuroimmunomodulation,2016,23(2):75-80.