Objective To analyze the statistical distribution of body mass index (BMI) in children with postural tachycardia syndrome (POTS) and children with vasovagal syncope (VVS), and to explore the application value of BMI in distinguishing the two diseases. Methods A total of 260 children and adolescents who complained of unexplained syncope were enrolled in this study from June 2015 to December 2019, and were divided into POTS group (n=110) and VVS group (n=150) after definite diagnosis by HUTT. Meanwhile, 82 subjects who took physical examination were selected as the control group. The data of BMI was collected after measuring the height and weight of all subjects in the same room, and its statistical difference among the three groups above was described. Then the receiver operating characteristic (ROC) curve was used to evaluate the value of BMI in distinguishing POTS and VVS. Results The average BMI of children in control group, POTS group and VVS group were (20. 51±2. 91) kg/m2, (18. 17±3. 12)kg/m2 and (19. 91±3. 69)kg/m2, respectively. The BMI of children in POTS group was significantly lower than that in control group and VVS group (P＜0. 001). However, there was no statistically significant difference between VVS group and control group (P＝0. 195). As for the BMI difference among the three VVS subtypes, the statistically difference was significant(F＝3. 229,P＝0. 042). The area under the ROC curve of BMI was 0. 644 (95%CI: 0. 577-0. 711, P＜0. 001). Taking 19. 30 kg/m2 as threshold BMI for VVS children and adolescents, the predicted sensitivity and specificity were 56. 0% and 71. 8%, respectively. Conclusions Children and adolescents with POTS have the significantly lower BMI than those with VVS. Thus, BMI is an acceptable auxiliary method to discriminate POTS and VVS combined with medical history, physical examination and other auxiliary examinations.
Key words
postural tachycardia syndrome /
vasovagal syncope /
body mass index /
children and adolescents
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