Influencing factors of gut microbiota of infants and its function in intestinal immunity

SUN Yan-ting, LIANG Hong-tao, WANG Chen, YAO Yi-bo, LU Jin-gen

Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (10) : 1110-1113.

PDF(562 KB)
PDF(562 KB)
Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (10) : 1110-1113. DOI: 10.11852/zgetbjzz2020-0293

Influencing factors of gut microbiota of infants and its function in intestinal immunity

  • SUN Yan-ting, LIANG Hong-tao, WANG Chen, YAO Yi-bo, LU Jin-gen
Author information +
History +

Abstract

Gut microbiota will experience a series of evolutions to form the final microbial homeostasis once it adapts to colonize in the intestinal tract.This review focuses on the gut microbiota in infants altered by factors in many aspects,for example,the stage of parturition,feeding patterns,dietary structure,living environment,diseases and drug use.In addition,the important role of gut microbiota in the formation of intestinal immunity is discussed.

Key words

infants / gut microbiota / influencing factors / immunoregulation

Cite this article

Download Citations
SUN Yan-ting, LIANG Hong-tao, WANG Chen, YAO Yi-bo, LU Jin-gen. Influencing factors of gut microbiota of infants and its function in intestinal immunity[J]. Chinese Journal of Child Health Care. 2020, 28(10): 1110-1113 https://doi.org/10.11852/zgetbjzz2020-0293

References

[1] Videhult FK,West CE.Nutrition,gut microbiota and child health outcomes[J].Curr Opin Clin Nutr Metab Care,2016,19(3):208-213.
[2] Collado MC,Rautava S,Aakko J,et al.Human gut colonisation may be initiated in utero by distinct microbial communities in the placenta and amniotic fluid[J].Sci Rep,2016,6:23129.
[3] Forsgren M,Isolauri E,Salminen S,et al.Late preterm birth has direct and indirect effects on infant gut microbiota development during the first six months of life[J].Acta Paediatr,2017,106(7):1103-1109.
[4] Rutayisire E,Huang K,Liu Y,et al.The mode of delivery affects the diversity and colonization pattern of the gut microbiota during the first year of infants′ life:a systematic review[J].BMC Gastroenterol,2016,16(1):86.
[5] Ho NT,Li F,Lee-Sarwar KA,et al.Meta-analysis of effects of exclusive breastfeeding on infant gut microbiota across populations[J],Nat Commun,2018,9(1):4169.
[6] Harmsen HJM,Wildeboer-Veloo AC,Raangs GC,et al.Analysis of intestinal flora development in breast-fed and formula-fed infants by using molecular identification and detection methods[J].J Pediatr Gastroenterol Nutr,2000,30(1):61-67.
[7] Leong C,Haszard JJ,Lawley B,et al.Mediation analysis as a means of identifying dietary components that affect the fecal microbiota of infants weaned by modified baby-led,compared to traditional,approaches[J].Appl Environ Microbiol,2018,84(18):e00914-e00918.
[8] Arumugam M,Raes J,Pelletier E,et al.Enterotypes of the human gut microbiome[J].Nature,2011,473(7346):174-180.
[9] Lindefeldt M,Eng A,Darban H,et al.The ketogenic diet influences taxonomic and functional composition of the gut microbiota in children with severe epilepsy[J].NPJ Biofilms Microbiomes,2019,5:5.
[10] De Filippo C,Di Paola M,Ramazzotti M,et al.Diet,environments,and gut microbiota.A preliminary investigation in children living in rural and urban burkina faso and Italy[J].Front Microbiol,2017,8:1979.
[11] Dong X,Shulzhenko N,Lemaitre J,et al.Arsenic exposure and intestinal microbiota in children from Sirajdikhan,Bangladesh[J].PLoS ONE,2017,12(12):e0188487.
[12] Tun HM,Konya T,Takaro TK,et al.Exposure to household furry pets influences the gut microbiota of infants at 3-4 months following various birth scenarios[J].Microbiome,2017,5(1):40-53.
[13] Arrieta MC,Stiemsma LT,Dimitriu PA,et al.Early infancy microbial and metabolic alterations affect risk of childhood asthma[J].Sci Transl Med,2015,7(307):307ra152.
[14] 彭韶,杜天华,张曼.反复肺炎患儿的肠道菌群与血清D-乳酸变化及相关性变化[J].中国当代儿科杂志,2016,18(2):113-116.
[15] Pop M,Walker AW,Paulson J,et al.Diarrhea in young children from low-income countries leads to large-scale alterations in intestinal microbiota composition[J].Genome Biol,2014,15(6):R76.
[16] Rigsbee L,Agans R,Shankar V,et al.Quantitative profiling of gut microbiota of children with diarrhea-predominant irritable bowel syndrome[J].Am J Gastroenterol,2012,107(11):1740-1751.
[17] Pammi M,Cope J,Tarr PI,et al.Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis:a systematic review and meta-analysis[J].Microbiome,2017,5(1):31.
[18] Knoll RL,Forslund K,Kultima JR,et al.Gut microbiota differs between children with inflammatory bowel disease and healthy siblings in taxonomic and functional composition:a metagenomic analysis[J].Am J Physiol Gastrointest Liver Physiol,2017,312(4):G327-G339.
[19] Kourosh A,Luna RA,Nance C,et al.Fecal microbiome signatures are different in food allergic children compared to siblings and healthy children[J].Pediatr Allergy Immunol,2018,29(5):545-554.
[20] West CE,Rydén P,Lundin D,et al.Gut microbiome and innate immune response patterns in IgE-associated eczema[J].Clin Exp Allergy,2015,45(9):1419-1429.
[21] Murri M,Leiva I,Gomez-Zumaquero JM,et al.Gut microbiota in children with type 1 diabetes differs from that in healthy children:a case-control study[J].BMC Med,2013,11(1):46.
[22] Greenwood C,Morrow AL,Lagomarcino AJ,et al.early empiric antibiotic use in preterm infants is associated with lower bacterial diversity and higher relative abundance of enterobacter[J].J Pediatr,2014,165(1):23-29.
[23] Wei S,Mortensen MS,Stokholm J,et al.Short- and long-term impacts of azithromycin treatment on the gut microbiota in children:a double-blind,randomized,placebo-controlled trial[J].EBioMedicine,2018,38:265-272.
[24] 王静,梁山玉,杨燕.运脾止泻汤对脾虚型迁延性腹泻患儿肠道菌群调整作用的临床研究[J].河北中医,2016,38(10):1474-1478.
[25] 罗文,许华,陈晓晴,等.消癜汤对过敏性紫癜儿童肠道菌群的影响[J].中医杂志,2014,55(22):1917-1920.
[26] Plummer EL,Bulach DM,Murray GL,et al.Gut microbiota of preterm infants supplemented with probiotics:sub-study of the ProPrems trial[J].BMC Microbiol,2018,18(1):184.
[27] Lau AS,Yanagisawa N,Hor YY,et al.Bifidobacterium longum BB536 alleviated upper respiratory illnesses and modulated gut microbiota profiles in Malaysian pre-school children[J].Benef Microbes,2018,9(1):61-70.
[28] Wrzosek L,Miquel S,Noordine ML,et al.Bacteroides thetaiotaomicron and Faecalibacterium prausnitzii influence the production of mucus glycans and the development of goblet cells in the colonic epithelium of a gnotobiotic model rodent[J].BMC Biol,2013,11:61.
[29] Mazmanian SK,Round JL,Kasper DL.A microbial symbiosis factor prevents intestinal inflammatory disease[J].Nature,2008,453(7195):620-625.
[30] Celli JP,Turner BS,Afdhal NH,et al.Helicobacter pylori moves through mucus by reducing mucin viscoelasticity[J].Proc Natl Acad Sci USA,106(34):14321-14326.
[31] Boneca IG,Dussurget O,Cabanes D,et al.A critical role for peptidoglycan N-deacetylation in Listeria evasion from the host innate immune system[J].Proc Natl Acad Sci USA,2007,104(3):997-1002.
[32] Iimura M,Gallo RL,Hase K,et al.Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens[J].J Immunol,2005,174(8):4901-4907.
[33] Round JL,Mazmanian SK.Inducible Foxp3+ regulatory T-cell development by a commensal bacterium of the intestinal microbiota[J].Proc Natl Acad Sci USA,2010,107(27):12204-12209.
[34] Cervantes-Barragan L,Chai JN,Tianero MD,et al.Lactobacillus reuteri induces gut intraepithelial CD4+CD8αα+ T cells[J].Science,357 (6353):806-810.
[35] Bunker JJ,Flynn TM,Koval JC,et al.Innate and adaptive humoral responses coat distinct commensal bacteria with immunoglobulin A[J].Immunity,2015,43(3):541-553.
PDF(562 KB)

Accesses

Citation

Detail

Sections
Recommended

/