Objective To investigate the relationship between Clara cell secretory protein (CCSP) and bronchopulmonary dysplasia (BPD) in premature infants, in order to provide reference for early prediction of BPD. Methods Totally 105 premature infants were enrolled in this study from the Neonatal Intensive Care Unit of Maternal and Child Health Care Hospital of Shandong Province from January to May in 2019.After discharge, the infants were divided into three groups according to the discharge diagnosis, including NRDS group (n=22), BPD group (n=20) and control group (n=63).The level of CCSP in cord blood serum was tested by enzyme-linked immunosorbent assay (ELISA).The level of CCSP in cord blood serum among three groups was compared, and the diagnostic efficacy of CCSP in BPD of premature infants as well as its correlation with gestational age and body weight were analyzed.Variance analysis, χ2 test and correlation analysis were used for statistical analysis. Results Compared with the control group [(46.237±19.991) ng/ml] and the NRDS group [(33.132±10.132) ng/ml], the level of CCSP in cord blood of BPD group was (20.332 ± 8.066) ng/ml, which was significantly different(F=19.926, P<0.001).LSD test showed thatthe level of CCSP in control group and NRDS group was higher than that in BPD group(P<0.05).The CCSP level in cord blood of premature infants was positively correlated with gestational age and birth weight(r=0.533, 0.550, P<0.01).When the cutoff value of CCSP level was 31.560 ng/ml, the diagnostic efficiency was the highest, the Jordan index was 0.582, the sensitivity and specificity was 90.0% and 68.2%, respectively.And the area under ROC was 0.886 (95%CI: 0.814-0.957, P<0.01). Conclusion The low concentration of CCSP in cord blood of preterm infants may reflect early lung injury, which is related to the occurrence of BPD and can be used as a potential marker for the prediction of BPD.
Key words
preterm infant /
Clara cell secretory protein /
bronchopulmonary dysplasia /
lung injury
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