Research progress on intestinal barrier dysfunction in necrotizing enterocolitis

YANG Meng-yang; JIANG Min

doi:10.11852/zgetbjzz2020-0115

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (3) : 281-284. DOI: 10.11852/zgetbjzz2020-0115

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Research progress on intestinal barrier dysfunction in necrotizing enterocolitis

YANG Meng-yang, JIANG Min

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Abstract

Necrotizing enterocolitis (NEC) is a common and serious disease of digestive system during neonatal period, which is one of the main cause of premature death. Intestinal barrier function is underdeveloped in preterm infants, and many pathogenic factors may induce intestinal barrier dysfunction, causing the intestinal mechanical barrier damage, the delay of microbial barrier establishment, the immature of immune barriers, thereby inducing inflammatory cascade reaction and the occurrence of NEC. Early diagnosis of NEC is extremely important for its treatment and prognosis, and the researches on intestinal barrier dysfunction markers are expected to improve the specificity and sensitivity of early diagnosis of NEC. This paper reviews the research progress on intestinal barrier dysfunction in NEC, in order to deepen the understanding of the role of intestinal barrier in the pathogenesis of NEC, and to provide more ideas for the prevention and treatment of NEC.

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necrotizing enterocolitis / intestinal barrier dysfunction / biomarkers / neonates

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YANG Meng-yang, JIANG Min. Research progress on intestinal barrier dysfunction in necrotizing enterocolitis[J]. Chinese Journal of Child Health Care. 2021, 29(3): 281-284 https://doi.org/10.11852/zgetbjzz2020-0115

References

[1] Lin PW, Stoll BJ. Necrotising enterocolitis[J]. Lancet, 2006, 368(9543):1271-1283.
[2] Berman L, Moss RL.Necrotizing enterocolitis: an update[J]. Semi Fetal and Neonatal Med, 2011, 16(3): 145-150.
[3] Bowker RM, Yan X, Managlia E, et al. Dimethyloxalylglycine preserves the intestinal microvasculature and protects against intestinal injury in a neonatal mouse NEC model: role of VEGF signaling[J]. Pediatr Res,2018, 83(2):545-553.
[4] Oda H, Takeichi M. Evolution:structural and functional diversity of cadherin at the adherens junction[J]. J Cell Biol, 2011, 193(7):1137-1146.
[5] Suzuki T.Regulation of intestinal epithelial permeability by tight junctions[J].Cell Mol Life Sci, 2013, 70(4):631-659.
[6] Turner JR. Intestinal mucosal barrier function in health and disease[J]. Nat Rev Immunol, 2009, 9(11):799-809.
[7] 中华医学会消化病学分会. 肠屏障功能障碍临床诊治建议[J]. 中华消化杂志, 2006, 26(9):620.
[8] Moore SA, Nighot P, Reyes C,et al. Intestinal barrier dysfunction in human necrotizing enterocolitis[J]. J Pediatr Surg, 2016,51(12): 1907-1913.
[9] Zhang HY, Wang F, Feng JX. Intestinal microcirculatory dysfunction and neonatal necrotizing enterocolitis[J]. Chin Med J(Engl), 2013, 126(9):1771-1778.
[10] Bhatia AM, Stoll BJ, Cismowski MJ, et al. Cytokine levels in the preterm infant with neonatal intestinal injury[J]. Am J Perinatol, 2014, 31(6):489-4962.
[11] Bein A, Eventov-Friedman S, Arbell D, et al. Intestinal tight junctions are severely altered in NEC preterm neonates[J].Pediatr Neonatol, 2018, 59(5):464-473.
[12] 史婧奕, 吕志宝. 肠屏障功能障碍与新生儿坏死性小肠结肠炎[J].国际儿科学杂志, 2015, 42(4):427-430.
[13] Anand RJ, Leaphart CL, Mollen KP, et al.The role of the intestinal barrier in the pathogenesis of necrotizing enterocolitis[J]. Shock, 2007, 27(2):124-133.
[14] Pammi M, Cope J, Tarr PI, et al.Intestinal dysbiosis in preterm infants preceding necrotizing enterocolitis: a systematic review and meta-analysis[J]. Microbiome,2017,(1):31.
[15] Alexander VN, Northrup V, Bizzarro MJ. Antibiotic exposure in the newborn intensive care unit and the risk of necrotizing enterocolitis[J]. J Pediatr, 2011, 159(3):392-397.
[16] Furfaro LL, Chang BJ, Payne MS. Applications for bacteriophage therapy during pregnancy and the perinatal period[J]. Front Microbiol, 2018, 8:2660.
[17] Max VB, Lybil MA, Josef N.Preterm neonatal immunology at the intestinal interface[J]. Cell Mol Life Sci, 2020,77(7):1209-1227.
[18] Sharma AA, Jen R, Butler A, et al. The developing human preterm neonatal immune system: a case for more research in this area[J]. Clin Immunol (Orlando, Fla), 2012, 145(1):61-68.
[19] Denning TL, Bhatia AM, Kane AF, et al.Pathogenesis of NEC: role of the innate and adaptive immune response[J]. Semin Perinatol, 2017, 41(1):15-28
[20] Chairatana P, Nolan EM. Defensins, lectins, mucins, and secretory immunoglobulin A: microbe-binding biomolecules that contribute to mucosal immunity in the human gut[J].Crit Rev Biochem Mol Biol, 2017, 52(1): 45-56.
[21] de Meij TG, van der Schee MP, Berkhout DJ, et al. Early detection of necrotizing enterocolitis by fecal volatile organic compounds analysis[J]. J Pediatr, 2015,167(3): 562-567.
[22] Treskes N, Persoon AM, van Zanten A.Diagnostic accuracy of novel serological biomarkers to detect acute mesenteric ischemia: a systematic review and meta-analysis[J]. Intern Emerg Med, 2017, 12(6): 821-836.
[23] Nakov R, Velikova T, Nakov V, et al. Serum trefoil factor 3predicts disease activity in patients with ulcerative colitis[J].Eur Rev Med Pharmacol Sci, 2019, 23(2): 788-794.
[24] van der Velden WJ, Herbers AH, Brüggemann RJ, et al. Citrulline and albumin as biomarkers for gastrointestinal mucositis in recipients of hematopoietic SCT[J]. Bone Marrow Transplant,2013,48(7): 977-981.
[25] 田云粉, 李利, 米弘瑛, 等. 肠型脂肪酸结合蛋白和粪钙卫蛋白联合检测在足月新生儿坏死性小肠结肠炎中的应用价值[J]. 中国当代儿科杂志, 2016, 18(11): 1080-1083. [26] Benkoe TM, Mechtler TP, Pones M, et al. The plasma activities of lysosomal enzymes in infants with necrotizing enterocolitis: new promising class of biomarkers?[J]. Clin China Acta, 2015,438:279-283.
[27] Smith SM, Eng RH, Buccini F, et al. Use of D-Lactic Acid Measurements in the Diagnosis of Bacterial Infectionss[J].J Infect Dis, 1986, 154(4):658-664.
[28] Denno DM, van Buskirk K, Nelson ZC, et al. Use of the lactulose to mannitol ratio to evaluate childhood environmental enteric dysfunction: a systematic review[J]. Clin Infect Dis, 2014, 59(Suppl 4): 213-219.
[29] Li Z, Sheng L. Significance of dynamic evolution of TNF-α, IL-6 and intestinal fatty acid-binding protein levels inneonatal necrotizing enterocolitis[J]. Exp Ther Med, 2018, 15(2): 1289-1292.
[30] Ng PC, Chan K, Yuen TP, et al. Plasma miR-1290 is a novel and specific biomarker for early diagnosis of necrotizing enterocolitis biomarker discovery with prospective cohort evaluation[J]. J Pediatr, 2019, 205: 83-90.
[31] Kong C, Li SM, Yang H, et al. Screening and combining serum biomarkers to improve their diagnostic performance in the detection of intestinal barrier dysfunction in patients after major abdominal surgery[J]. Ann Transl Med, 2019, 7(16):388.
[32] 张丽秀,王称,王陆军,等. 肠道屏障功能生化指标在新生儿坏死性小肠结肠炎分级中的意义[J]. 中国妇幼卫生杂志, 2018, 9(6):24-27.