Objective To evaluate the correlation between serum vitamin D(Vit D) level and the risk of allergic rhinitis (AR) in children by Meta-analysis. Methods Case-control studies on the correlation between serum Vit D level and childhood AR published till 15th May in 2019 were searched in computer databases.Literature was selected according to strict inclusion and exclusion criteria and data were cross-extracted to perform Meta-analysis. Results Totally 11 articles involving 3 262 participants were included,of whom 1 718 in AR group and 1 544 in control group.Meta-analysis results indicated that serum Vit D level in AR group were significantly higher than that in control group (SMD=-1.31,95%CI:-1.85--0.77,P<0.001).Vit D2 level of AR group was significantly lower than that of control group(SMD=-0.17,95%CI:-0.32--0.01,P<0.001).Moreover,Vit D3 level of AR group was significantly lower than that of control group(SMD=-3.09,95%CI:-3.57--2.61,P<0.001).Subgroup analysis showed the heterogeneity of the experimental results was reduced,which may be influenced by factors such as diet and lighting in different regions. Conclusion Vit D level in children with AR is significantly lower than that in control group,especially Vit D3,suggesting Vit D3 deficiency may be an important factor for AR in children.
Key words
vitamin D /
allergic rhinitis /
Meta-analysis
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