Objective To analyze the value of general movements(GMs) combined with Gesell Developmental Scale (GDS) in predicting the outcome of motor development in high-risk premature infants,so as to provide scientific basis for early screening of high-risk premature infants with dyskinesia. Methods A total of 64 high risk infants Women and Infants Hospital of Zhengzhou were enrolled in this study from November 2016 to November 2018.GMs assessment was performed at the stage of twisting and uneasy movement.Infants were followed-up to the age of 12 months,and the clinical diagnosis and GDS were used to determine the outcome of motor development.The value of GMs assessment in predicting the motor development outcome of high-risk preterm infants were caculated. Results Among 64 preterm high-risk infants,3(4.69%) cases were found with cerebral palsy,16(25.00%) cases were with motor development retardation,and 45(70.31%) cases were found with normal motor development.In terms of predicting abnormal results of motor development,the specificity of the restless movement stage and twisting stages was 97.78%,84.44%,respectively,and the sensitivity was 15.79%,52.63%,negative predictive value was 73.33%,80.85%,positive predictive value was 75.00%,58.82%.In terms of prediction of cerebral palsy,the highest specificity of the assessment was 96.72% in the stage of the restless movement and the stage of the CS movement. Conclusion GMs combined with GDS helps to predict the motor development outcome of preterm high-risk infants.