Research advance in unconventional regulation of small non-coding RNAs in obesity

XIE Han-ying; WANG Xing-yun; WANG Jun; HAN Shu-ping; CHEN Xiao-hui

doi:10.11852/zgetbjzz2019-1880

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (2) : 160-164. DOI: 10.11852/zgetbjzz2019-1880

Review

Research advance in unconventional regulation of small non-coding RNAs in obesity

XIE Han-ying^*, WANG Xing-yun, WANG Jun, HAN Shu-ping, CHEN Xiao-hui

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Abstract

Obesity is a chronic metabolic disorder disease characterized by excessive fat accumulation,causing heavy burden to the health.In general,small non-coding RNAs (miRNAs) negatively regulate protein-coding gene expression at post-transcriptional level through being incorporated in RNA-induced silencing complex,which play an important role in the development of obesity.Recent studies suggest that miRNAs also can function in an unconventional manner,including interacting with the 5'untranslated region of messenger RNAs (mRNAs) and enhancing their translation,indirectly regulating mRNAs in transcriptional level,targeting on non-coding RNAs (ncRNAs),regulating mitochondrial gene translation,encoding peptides and serving as ligands for Toll-like receptors.The discovery of these unconventional roles of miRNAs opens a new promising field of miRNAs research.In this review,recent literatures on these unconventional roles of miRNAs and the mechanisms associated with obesity are summarized.

Key words

obesity / metabolic syndrome / small non-coding RNA / non-coding RNA / lipid metabolism

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XIE Han-ying, WANG Xing-yun, WANG Jun, HAN Shu-ping, CHEN Xiao-hui. Research advance in unconventional regulation of small non-coding RNAs in obesity[J]. Chinese Journal of Child Health Care. 2021, 29(2): 160-164 https://doi.org/10.11852/zgetbjzz2019-1880

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