Relationship between exposure levels of bisphenol A and the risk of idiopathic precocious puberty in school-age girls

ZHOU Lan-mei; WANG Qiong-jin; JI Cui-fang

doi:10.11852/zgetbjzz2019-1846

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (11) : 1250-1254. DOI: 10.11852/zgetbjzz2019-1846

Relationship between exposure levels of bisphenol A and the risk of idiopathic precocious puberty in school-age girls

ZHOU Lan-mei, WANG Qiong-jin, JI Cui-fang

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Abstract

Objectives To analyze the relationship between exposure to bisphenol A (BPA) and idiopathic central precocious puberty (ICPP) in school-age girls,thus to provide a basis for preventing ICPP in girls. Methods Totally 110 school-age children diagnosed with ICPP in the Affiliated Hospital of Yangzhou University were enrolled in this study from July 2016 and September 2018,meanwhile 110 healthy girls were selected as controls matched with age and body mass index (BMI).Urinary BPA concentrations of all girls were tested and its association with the risk of ICPP was analyzed.Laboratory examinations including serum estradiol (E2) level,basal and gonadotropin-releasing hormone (GnRH) stimulated luteinizing hormone(LH),and follicle-stimulating hormone (FSH) levels,bone age (BA),and uterine and ovarian sizes were conducted in ICPP girls. Results Median concentrations of urinary BPA in ICPP group and control group were 6.25 μg/g Cr and 1.07 μg/g Cr,respectively (Z=-3.845,P＜0.001).After adjustment for confounders,the risk of ICCP in girls with highest concentrations of BPA was 9.07 times higher than those with the lowest concentrations of BPA(OR=9.07,95%CI:2.82-29.14).Moreover,negative correlations were found between urinary BPA concentrations and basal FSH level (r=-0.235,P=0.005) or peak FSH level (r=-0.171,P=0.044) in girls with ICCP. Conclusion BPA exposure is associated with an increasing risk of ICPP in school-age girls,and the potential mechanism may be attributed to the relatively low level of FSH.

Key words

urine bisphenol A / idiopathic central precocious puberty / school-age girls

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ZHOU Lan-mei, WANG Qiong-jin, JI Cui-fang. Relationship between exposure levels of bisphenol A and the risk of idiopathic precocious puberty in school-age girls[J]. Chinese Journal of Child Health Care. 2020, 28(11): 1250-1254 https://doi.org/10.11852/zgetbjzz2019-1846

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