Research advances on the role of vitamin D in autism spectrum disorders

XIA Yang; YANG Shu-fen

doi:10.11852/zgetbjzz2019-1760

PDF(459 KB)

Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (10) : 1122-1125. DOI: 10.11852/zgetbjzz2019-1760

Research advances on the role of vitamin D in autism spectrum disorders

XIA Yang, YANG Shu-fen

Author information +

History +

Abstract

Autism spectrum disorders (ASD) is one of the serious public problems affecting children′s health,characterized by social communication disorder,narrow interest or activity range and repetitive stereotyped behavior.In recent years,increasing studies have shown that the level of vitamin D (Vit D) in ASD children is significantly lower than that of healthy children with the same age,and vitamin D deficiency may be related to the pathogenesis of ASD.This paper reviews the research progress on vitamin D and ASD.

Key words

autism spectrum disorders / vitamin D / neurodevelopment

Cite this article

EndNote

Ris (Procite)

Bibtex

Download Citations

XIA Yang, YANG Shu-fen. Research advances on the role of vitamin D in autism spectrum disorders[J]. Chinese Journal of Child Health Care. 2020, 28(10): 1122-1125 https://doi.org/10.11852/zgetbjzz2019-1760

References

[1] Baio J,Wiggins L,Christensen DL,et al.Prevalence of autism spectrum disorder among children aged 8 years-Autism and Developmental Disabilities Monitoring Network,11 Sites,United States[J].MMWR Surveill Summ,2018,67(6):1-23.
[2] 戴琼,徐海青,汪鸿,等.2000-2016年中国儿童孤独症谱系障碍患病率Meta分析[J].中国儿童保健杂志,2017,25(12):1243-1246.
[3] Mácová L,Biciková M,OstatniKová D,et al.Vitamin D neurosteroids and autism[J].Physiol Res,2017,66(Suppl 3):333-340.
[4] Yates NJ,Tesic D,Feindel KW,et al.Vitamin D is crucial for maternal care and offspring social behaviour in rats[J].Endocr,2018,237(2):73-85.
[5] Hawes JE,Tseic D,Whitehouse AJ.et al.Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J].Behav Brain Res,2015,286:192-200.
[6] Cannell JJ.Vitamin D and autism,what′s new?[J].Rev Endocr Metab Disord,2017,18:183-193.
[7] Sharmi B,Bushra K,Charan J,et al.Fok-I,Bsm-I,and Taq-I variants of vitamin D receptor polymorphism in the development of autism spectrum disorder:a literature review[J].Cureus,2018,10(8):e3228.
[8] Kałuzna-Czaplińska J,Jóźwik-Pruska J,Chirumbolo S,et al.Tryptophan status in autism spectrum disorder and the influence of supplementation on its level[J].Metab Brain Dis,2017,32:1585-1593.
[9] 吴光驰.维生素D缺乏离我们有多远[J].中国妇幼卫生杂志,2014,5(5):72-76.
[10] Wang T,Shan L,Du L,et al.Serum concentration of 25-hydroxyvitamin D in autism spectrum disorder:a systematic review and meta-analysis[J].Eur Child Adolesc Psychiatry,2016,25:341-350.
[11] Arastoo AA,Khojastehkia H,Rahimi Z,et al.Evaluation of serum 25-Hydroxy vitamin D levels in children with autism Spectrum disorder,Italian[J].Pediatr,2018,44:150.
[12] Guo M,Zhu J,Yang T,et al.Vitamin A and vitamin D deficiencies exacerbate symptoms in children with autism spectrum disorders[J].Nutr Neurosci,2019,22(9):637-647.
[13] Wu DM,Wen X,Han XR,et al.Relationship between neonatal vitamin D at birth and risk of autism spectrum disorders:the NBSIB study[J].Bone Miner Rese,2017,33(3):458-466.
[14] García-Serna AM,Morales E.Neurodevelopmental effects of prenatal vitamin D in humans:systematic review and meta-analysis[J].Mol Psychiatr,2019.doi:/10.1038/s41380-019-0357-9.
[15] Vinkhuyzen AAE,Eyles DW,Burne THJ,et al.Gestational vitamin D deficiency and autism-related traits:the Generation R Study[J].Mol Psychiatr,2018.doi:10.1038/mp.2016.213.
[16] Mónica López-Vicente,Sunyer J,Lertxundi N,et al.Maternal circulating vitamin D levels during pregnancy and behaviour across childhood[J].Sci Rep,2019,9:14792.
[17] Altun H,Kurutas EB,Sahin N,et al.The levels of vitamin D,vitamin D receptor,homocysteine and complex B vitamin in children with autism spectrum disorders[J].Cli Psychopharm Neur,2018,16(4):383-390.
[18] Zhang Z,Li S,Yu L,et al.Polymorphisms in vitamin D receptor genes in association with childhood autism spectrum disorder[J].Hindawi Disease,2018.doi:10.1155/2018/7862892.
[19] Mobasheri L,Moossavi SZ,Esmaeili A,et al.Association between vitamin D receptor gene FokI and TaqI variants with autism spectrum disorder predisposition in Iranian population[J].Gene,2019,doi:https://doi.org/10.1016/j.gene.2019.144133
[20] Ali A,Cui X,Eyles D.Developmental vitamin D deficiency and autism:putative pathogenic mechanisms[J].Steroid Biochem Mol Biol,2018,175:108-118.
[21] Hawes JE,Tseic D,Whitehouse AJ,et al.Maternal vitamin D deficiency alters fetal brain development in the BALB/c mouse[J].Behav Brain Res,2015,286:192-200.
[22] Delucs HF.Vitamin D:historical overview[J].Vitam Horm,2016,100:1-20.
[23] Rossignol DA,Frye RE.A review of research trends in physiological abnormalities in autism spectrum disorders:immune dysregulation,inflammation,oxidative stress,mitochondrial dysfunction and environmental toxi-cant exposures[J].Mol Psychiatr,2012,17:389-401.
[24] Pertile RAN,Cui X,Hammond L,et al.Vitamin D regulation of GDNF/Ret signaling in dopaminergic neurons[J].Faseb J,2018,32(2):819-828.
[25] Patrick RP,Ames BN.Vitamin D hormone regulates serotonin synthesis.Part 1:Relevance for autism[J].FASEB Journal,2014,28:2398-2413.
[26] Saad K,Abdel-Rahman AA,Elserogy YM,et al.Randomized controlled trial of vitamin D supplementation in children with autism spectrum disorder[J].Child Psychol Psychiatry,2018,59(1):20-9.
[27] Feng J,Shan L,Du L,et al.Clinical improvement following vitamin D3 supplementation in autism Spectrum disorder[J].Nutr Neurosci,2016,20(5):284-290.
[28] Yamasue H,Okada T,Munesue T,et al.Effect of intranasal oxytocin on the core social symptoms of autism spectrum disorder:a randomized clinical trial[J].Molecular Psychiatry,2018,23(8):1-10.
[29] Mazahery H,Conlon CA,Beck KL,et al.A randomised controlled trial of vitamin D and omega-3 long chain polyunsaturated fatty acids in the treatment of irritability and hyperactivity among children with autism spectrum disorder[J].J Steroid Biochem,2019.doi:/10.1016/j.jsbmb.2018.10.017.
[30] Feiyong Jia,Ling Shan,Bing Wang,et al.Fluctuations in clinical symptoms with changes in serum 25(OH) vitamin D levels in autistic children:three cases report[J].Nutr Neurosci,2018.doi:10.1080/1028415X.2018.1458421
[31] Conor PK,Basil E,Peter G,et al.Blunted serum 25-(OH)D response to vitamin D3 supplementation in children with autism[J].Nutr Neurosci,2018.doi:10.1080/1028415X.2018.1529342.
[32] Fraguas D,Díaz-Caneja CM,Pina-Camacho L,et al.Dietary interventions for autism spectrum disorder:a Meta-analysis[J].Pediatrics,2019,144(5):e20183218.
[33] Geir B,Waly MI,Al-Farsi Y,et al.The role of vitamins in autism spectrum disorder:what do we know[J].J Mol Neurosci,2019.doi:/10.1007/s12031-018-1237-5.
[34] Roberta R,Jacques RN,Gesivaldo S,et al.Impact of vitamin deficiency on microbiota composition and immunomodulation:relevance to autistic spectrum disorders[J].Nutr Neurosci,2019.doi:10.1080/1028415X.2019.1660485.