Role of vitamin A in the treatment of iron deficiency and iron deficiency anemia

ZHU Dan; YU Wen

doi:10.11852/zgetbjzz2019-1755

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Chinese Journal of Child Health Care ›› 2021, Vol. 29 ›› Issue (1) : 56-59. DOI: 10.11852/zgetbjzz2019-1755

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Role of vitamin A in the treatment of iron deficiency and iron deficiency anemia

ZHU Dan, YU Wen

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Abstract

In recent years,it has been found that there is a significant correlation between vitamin A deficiency and iron deficiency.Vitamin A used to treat iron deficiency anemia and iron deficiency has achieved good clinical effect.This article reviews the correlation and mechanism between vitamin A deficiency and iron deficiency,as well as the clinical effect and research progress on vitamin A in the treatment of iron deficiency anemia,thus to provide basis for vitamin A in the treatment of iron deficiency anemia in children,and to give more effective reference for reducing the rate of iron deficiency anemia and iron deficiency.

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vitamin A / iron deficiency anemia / iron deficiency / children

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ZHU Dan, YU Wen. Role of vitamin A in the treatment of iron deficiency and iron deficiency anemia[J]. Chinese Journal of Child Health Care. 2021, 29(1): 56-59 https://doi.org/10.11852/zgetbjzz2019-1755

References

[1] 中华预防医学会儿童保健分会.婴幼儿喂养与营养指南[J].中国妇幼健康研究,2019,30(4):392-417.
[2] 赵惠君.儿童缺铁和缺铁性贫血的防治[J].实用儿科临床杂志,2012,27(3):163-165.
[3] 国务院.中国儿童发展纲要(2011-2020年)[R/OL].(2011-07-30)[2019-11-19].http://www.gov.cn/gongbao/content/2011/content_1927200.htm
[4] 中华医学会血液学分会红细胞疾病(贫血)学组.铁缺乏症和缺铁性贫血诊治和预防多学科专家共识[J].中华医学杂志,2018,98(8):2233-2237.
[5] Siu AL,US Preventive Services Task Force.Screening for iron deficiency anemia in young children:USPSTF recommendation statement[J].Pediatrics,2015,136(4):746-752.
[6] 高芳,高向东,李翔.婴幼儿缺铁性贫血与其智能发育的关系分析[J].临床医药实践,2016,25(12):909-911.
[7] 胡洪波,郭虹,石祖亮,等.缺铁性贫血患儿淋巴细胞体外增殖及细胞因子分泌水平研究[J].中国儿童保健杂志,2019,27(7):786-788.
[8] Mohus RM,Paulsen J,Gustad L,et al.Association of iron status with the risk of bloodstream infections:results from the prospective populationbased HUNT Study in Norway[J].Intensive Care Med,2018,44(8):1276-1283.
[9] Unger SL,Fenton TR,Jetty R,et al.Iron requirements in the first 2 years of life[J].Paediatrics &Child Health,2019,24(8):555-556.
[10] Villagomez A,Ramtekkar U.Iron,magnesium,vitamin d,and zinc deficiencies in children presenting with symptoms of attention-deficit/hyperactivity disorder[J].Children(Basel),2014,1(3):261-279.
[11] Serkan G,Ekinci O,Celik TJ,et al.Iron deficiency parameters in autism spectrum disorder:clinical correlates and associated factors[J].Ital J Pediatr,2017,43(1):86.
[12] 中华儿科杂志编辑委员会.儿童缺铁和缺铁性贫血防治建议[J].中国儿童保健杂志,2010,18(8):724-726.
[13] 王卫平.儿科学[M].北京:人民卫生出版社,2018.
[14] 向伟.儿童铁缺乏症及缺铁性贫血防治进展[J].中华儿科杂志,2008,46(7):507-509.
[15] 麦燕.孕期营养干预对妊娠期缺铁性贫血效果评价分析[J].中国医药导刊,2017,19(11):1111-1113.
[16] 中华医学会血液学分会红细胞疾病(贫血)学组.铁缺乏症和缺铁性贫血诊治和预防多学科专家共识[J].中华医学杂志,2018,98(28):2233-2237.
[17] 宰宇,翦耀文,高露,等.中国人群维生素A与贫血关系的Meta分析[J].营养学报,2016,38(5):438-442.
[18] Saraiva BC,Soares MC,Santos LC,et al.Iron deficiency and anemia are associated with low retinol levels in children aged 1 to 5 years[J].J Pediatr(Rio J),2014,90(6):593-599.
[19] 林良明,宋小芳,刘玉林,等.中国儿童维生素A缺乏与贫血关系分析[J].中国儿童保健杂志,2003,11(4):242-244.
[20] Hodges RE,Sauberlich HE,Canhan JE,et al.Hematopoietic studies in vitamin A deficiency[J].Am J Clin Nutr,1978,31(5):876-885.
[21] Cunha MSB,Siqueira EMA,Trindade LS,et al.Vitamin A deficiency modulates iron metabolism via ineffective erythropoiesis[J].J Nutr Biochem,2014,25(10):1035-1044.
[22] Jang JT,Green JB,John L,et al.Kinetic analysis shows that iron deficiency decreases liver vitamin A mobilization in rats[J].J Nutr,2000,130(5):1291-1296.
[23] Roodenburg AJC,West CE,Hovenier R,et al.Strategies for the prevention of iron deficiency through foods in the household[J].Nutr Rev,1997,55(6):233-239.
[24] GarcíaCasal MN,Layrisse M,Solano L,et al.Vitamin A and beta-carotene can improve nonheme iron absorption from rice,wheat and corn by humans[J].J Nutr,1998,128(3):646.
[25] 宁珂,李晖.维生素A和铁对缺铁性贫血儿童转铁蛋白受体和免疫功能的影响[J].海南医学院学报,2012,18(9):1266-1270.
[26] Andersen AB,Schmidt LK,Faurholt-Jepsen D,et al.The effect of daily consumption of the small fish Amblypharyngodon mola or added vitamin A on iron status:a randomised controlled trial among Bangladeshi children with marginal vitamin A status[J].Asia Pac J Clin Nutr,2016,25(3):464-471.
[27] Cañete A,Cano E,Muñoz-Chápuli R,et al.Role of vitamin A/retinoic acid in regulation of embryonic and adult hematopoiesis[J].Nutrients,2017,9(2):E159.
[28] Cabezas-Wallscheid N,Buettner F,Sommerkamp P,et al.Vitamin A-retinoic acid signaling regulates hematopoietic stem cell dormancy[J].Cell,2017,169(5):807-823.
[29] Ginzburg YZ.Hepcidin-ferroportin axis in health and disease[J].Vitam Horm,2019,110:17-45.
[30] Wiseman EM,Dadon BE,Reifen R.The vicious cycle of vitamin A deficiency:a review[J].Crit Rev Food Sci Nutr,2017,57(17):3703-3714.
[31] da Cunha MSB,Campos Hankins NA,Arruda SF.Effect of vitamin A supplementation on iron status in humans:a systematic review and meta-analysis[J].Crit Rev Food Sci Nutr,2019,59(11):1767-1781.
[32] Zimmermann MB,Biebinger R,Rohner F,et al.Vitamin A supplementation in children with poor vitamin A and iron status increases erythropoietin and hemoglobin concentrations without changing total body iron[J].Am J Clin Nutr,2006,84(3):580-586.
[33] Chen K,Xie HM,Tian W,et al.Effect of single-dose albendazole and vitamin A supplementation on the iron status of pre-school children in Sichuan,China[J].Br J Nutr,2016,115(8):1415-1423.
[34] Chen K,Zhang L,Luo H,et al.Effect of vitamin A supplements on iron metabolic homeostasis for preschoolers[J].Zhonghua Yu Fang Yi Xue Za Zhi,2014,48(1):18-22.Chinese.
[35] Zhang X,Chen K,Qu P,et al.Effect of biscuits fortified with different doses of vitamin A on indices of vitamin A status,haemoglobin and physical growth levels of pre-school children in Chongqing[J].Public Health Nutr,2010,13(9):1462-1471.
[36] 范萍,汪福玲,等.铁剂+维生素A与单纯铁剂改善铁营养状况整合Meta分析[J].中国预防医学杂志,2010,11(12):1213-1216.