Objective To analyze the concordance, genetic heritability with autism spectrum disorder(ASD),establish regression model among 36 pairs of twins,and to explore related factors of outcome of neurodevelopmental scale. Methods Partial twins were collected from Children's Hospital of Fudan University from 2016 to 2018, and those who met the inclusion criteria that at least one twin was ASD or both twins were neuro-typical (NT) were enrolled in this study. General data of the participants were collected, and sociability and development quotient (DQ) were assessed by Autism Diagnostic Observation Schedule (ADOS) and Griffiths Mental Developmental Scales (GMDS). The model was established by R language and software package-mets. Results The concordance rate of monozygotic twins was 66. 7%, while 16. 7% for dizygotic twins among 36 pairs. The best fist of ASD risk factors was AE model including gender and weight covariance and the heritability of ASD diagnosis was 90. 4%(95%CI:65. 2%~115. 7%), but clinical covariates and genetic factors had no significant effect on ASD prediction. AE fitted model of ADOS-RRB best included ASD diagnosis, weight, birth type and age, while CE fitted model of ADOS-SA included gender, age, maternal education, and way of conception. CE fitted model of GMDS-DQ included ASD diagnosis, premature and gender. And non-shared environmental factors had significant effects on clinical characteristics of ASD (ADOS-RRB, P=0. 000 2; ADOS-SA, P<0. 000 1; GMDS-DQ,P<0. 000 1). Conclusion Genetic factor is an important factor in the occurrence of ASD, and non-shared environmental factor has a certain correlation with the clinical evaluation results of ASD.
Key words
autism spectrum disorder /
twin pairs /
heritability /
AE model /
CE model
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