Research progress on the microbiota-gut-brain axis in pathogenesis of neonatal hypoxic ischemic encephalopathy

LI Meng; HE Xue-jia; ZHU Wei-wei

doi:10.11852/zgetbjzz2019-1540

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (11) : 1223-1226. DOI: 10.11852/zgetbjzz2019-1540

Research progress on the microbiota-gut-brain axis in pathogenesis of neonatal hypoxic ischemic encephalopathy

LI Meng, HE Xue-jia, ZHU Wei-wei

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Abstract

Neonatal hypoxic ischemic encephalopathy (HIE) is one of the diseases with high disability rate and mortality rate in the neonatal period.Recent studies have shown that the hypoxic ischemic injury of the newborn brain is related to the oxidative stress of the nervous system and mitochondrial dysfunction of tissue involved in the “microbiota-gut-brain axis”,but its molecular mechanism is still unclear.The most critical link of HIE is the occurrence of secondary energy failure,and the “latency period” between the two energy failure is the so-called “time window” for treatment,which is the best time when the neuroprotective measures to reduce brain injury can be successfully applied.This paper reviews the research progress on “microbiota-gut-brain axis” participating in oxidative stress in the pathogenesis of HIE,thereby providing a new dimension to the interaction between intestinal flora and brain,and opening a door for the prevention and treatment of HIE.

Key words

microbiota-gut-brain axis / neonatal hypoxic ischemic encephalopathy / oxidative stress / short chain fatty acids

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LI Meng, HE Xue-jia, ZHU Wei-wei. Research progress on the microbiota-gut-brain axis in pathogenesis of neonatal hypoxic ischemic encephalopathy[J]. Chinese Journal of Child Health Care. 2020, 28(11): 1223-1226 https://doi.org/10.11852/zgetbjzz2019-1540

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