Objective To analyze the effect of INSURE strategy in combination with budesonide on the incidence of bronchopulmonary dysplasia(BPD) during the treatment of respiratory distress syndrome in very low birth weight, in order to provide scientific basis for clinical treatment to reduce the incidence of BPD. Methods 1) A total of 83 neonates diagnosed with RDS admitted to Peking University Third Hospital within 1 h after birth from January 2014 to December 2018, whose gestational age was less than 32 weeks and birth weight was from 1 000 to 1 500 g, were selected in this study, and were divided into the modified group with 35 cases (intubation-surfactant and budesonide-extubation) and conventional group with 48 cases (intratracheal administration of surfactant and mechanical ventilation).2) A clinical questionnaire was designed to collect general information, incidences of BPD and other complications, outcomes and so on. Results 1) PO2 in the modified group was higher than that in the conventional group at 6 h after administration, and both ventilator and total oxygen use time were significantly shorter than those in the conventional group (t=2.571, 3.633, 3.484, P＜0.05).2) The incidence of BPD and patent ductus arteriosus in the modified group was significantly lower than those in the conventional group (χ2=3.886, 3.920, P＜0.05).But there were no statistically significant differences on the incidence of other complications and survival rate between the two groups(P＞0.05). Conclusions INSURE strategy in combination with budesonide can improve oxygenation in early stage, shorten ventilator and total oxygen use time, significantly reduce the incidence of BPD, and also reduce the incidence of patent ductus arteriosus, which does not increase the risk of other diseases and death in the short term.Therefore, further researches are warranted so as to promote its application on clinical practice.
Key words
bronchopulmonary dysplasia /
intubation-surfactant-extubation /
budesonide /
very low birth weight infant /
respiratory distress syndrome
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