Objective To explore the influence of intrauterine growth retardation(IUGR) on physical development of premature infants,in order to provide scientific reference for early intervention. Methods A total of 449 preterm infants born in Xi'an Fourth Hospital from 2015 to 2017 and filed in Healthcare Center of Children were selected as observation group,of whom 91 cases were small for gestational age(SGA) newborns and 358 were appropriate for gestational age(AGA) infants.Meanwhile,300 full-term neonates were randomly selected as the control group.The physical development monitoring and individualized feeding guidance for three groups of children were followed up to corrected gestational age of 12 months old.The difference on the developmental delay(DD) rate between SGA group and AGA group was analyzed,and the growth rate of three groups of children was compared. Results 1) There was significant difference on the incidence of DD regarding body weight,length,and head circumference of premature infants among different age groups,which decreased with the increasing of age(χ²_SGA=24.242,46.761,9.891,P<0.05;χ²_AGA=17.536,45.763,13.829,P<0.05);2) The rate of DD on body weight,length,and head circumference between SGA and AGA infants at the same age was significantly different(P<0.05).3) The growth rate within corrected age of 6 months old among SGA group,AGA group and full-term infant group was significantly different(P<0.05). Conclusions Preterm infants show catch-up growth after birth,and SGA preterm infants appears to have the strongest catch-up trend.However,20% of SGA preterm infants still have physical retardation at the age of one year old.