Study on vitamin D level and appropriate supplementary dose of full-term neonates in Wuxi

ZHANG Yan-yu; WANG Xiao-lei; ZHANG Le; CHEN Jing

doi:10.11852/zgetbjzz2019-1171

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Chinese Journal of Child Health Care ›› 2020, Vol. 28 ›› Issue (7) : 805-808. DOI: 10.11852/zgetbjzz2019-1171

Study on vitamin D level and appropriate supplementary dose of full-term neonates in Wuxi

ZHANG Yan-yu, WANG Xiao-lei, ZHANG Le, CHEN Jing

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Abstract

Objective To investigate the nutritional status and influencing factors of neonatal vitamin D (VD) in Wuxi,in order to provide scientific basis for formulating the supplementation program suitable for neonates in this region. Methods A total of 347 full-term infants who were breastfed and aged≤7 days were selected in Wuxi Children's Hospital from March 2015 to March 2018.The serum 25-(OH)D level of the infants was tested,and those whose serum 25-(OH)D level≤50 nmol/L were divided into 400 U/d supplementation group and 800 U/d supplementation group.After six-week supplementation,25-(OH)D level of infants was retested.Mothers were investigated about their general situations and vitamin D intake in pregnancy by questionnaire. Results The proportions of vitamin D deficiency,insufficiency and sufficiency were 91.07%,8.07% and 0.86%,respectively.The serum levels of 25-(OH)D in neonates born in summer and autumn were significantly higher than those born in winter and spring(t=-3.467,P<0.05).Six weeks later,it was found that the overall level of serum 25-(OH)D increased,the proportion of vitamin D deficiency decreased (χ²=118.235,163.196, P<0.05).There was some correlation between the levels of calcium and vitamin D supplementation in mothers and 25-(OH)D level in infants(r=0.116,P=0.043). Conclusion s The vitamin D level of full-term newborns in Wuxi is generally deficient.In order to improve the situation,it is suggested to adjust the vitamin D supplementation dose of early-term newborns to 400-800 U/d for 6 weeks according to the supplementation of mothers during pregnancy.

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full-term infants / neonates / vitamin D / 25-(OH)D

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ZHANG Yan-yu, WANG Xiao-lei, ZHANG Le, CHEN Jing. Study on vitamin D level and appropriate supplementary dose of full-term neonates in Wuxi[J]. Chinese Journal of Child Health Care. 2020, 28(7): 805-808 https://doi.org/10.11852/zgetbjzz2019-1171

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