Objective To analyze the effects of T tumor necrosis factor-induced protein 8 like-2(TIPE2) and immunoglobulin E(IgE) on the occurrence and development of asthma in children,in order to provide evidence for the diagnosis and treatment of children with asthma. Methods A total of 100 children with asthma treated in Zhengzhou Children's Hospital from January 2016 to December 2018 were enrolled in this study,and 98 children who took physical examinations at the same period were selected as control group.The expression levels of TIPE2 mRNA and protein,and the serum IgE level were tested in two groups of children,and the accuracy and sensitivity of various indicators were analyzed. Results The levels of TIPE2 mRNA and protein expression of mononuclear cells in patients with asthma were significantly lower than those in control group (t=15.165,21.265,P<0.001).The expression of IgE in asthma group was significantly higher than that in control group (t=138.139,P<0.001).The specificity and sensitivity of TIPE2 in combination with IgE for asthma diagnosis were significantly higher than those of only using TIPE2 or IgE for asthma diagnosis (χ2=14.624,13.455,18.000,14.559,P<0.001).After drug treatment,it was found that the expression level of TIPE2 in children with asthma increased significantly compared with that before treatment,while the expression of IgE decreased significantly (t=12.975,112.480,P<0.001). Conclusion s TIPE2 and IgE have important effects on the development of asthma children.The changes should be closely monitored during the treatment process,so as to provide new ideas for the diagnosis and treatment of asthma in children.
Key words
T tumor necrosis factor-induced protein 8 like-2 /
immunoglobulin E /
asthma
{{custom_sec.title}}
{{custom_sec.title}}
{{custom_sec.content}}
References
[1] Barnish MS,Tagiyeva N,Devereux G,et al.Diverging prevalences and different risk factors for childhood asthma and eczema:a cross-sectional study[J].BMJ Open,2015,5(6):446-449.
[2] Huang C,Liu W,Hu Y,et al.Updated prevalences of asthma,allergy,and airway symptoms,and a systematic review of trends over time for childhood asthma in Shanghai,China[J].PLoS One,2015,10(4):577-579.
[3] 中华医学会呼吸病学分会哮喘学组.支气管哮喘防治指南(2016年版)[J].中华结核和呼吸杂志,2016,46(9):675-697.
[4] 时光,赵俊伟,明亮.支气管哮喘患者外周血单个核细胞TIPE2、TF的表达[J].郑州大学学报:医学版,2017,52(6):685-689.
[5] 郜珊珊,周娟,袁祖贻,等.IgE-FcεRI交联促进过敏性哮喘小鼠动脉粥样硬化的发生发展[J].中国病理生理杂志,2018,34(9):1552-1557.
[6] 李颖.过敏性哮喘患儿呼出气一氧化氮变化及与血清过敏原特异性IgE的相关性[J].山东医药,2017,57(35):66-68.
[7] 张子友,朱厚才,杨先文,等.孟鲁司特片联合布地奈德雾化吸入治疗对儿童支气管哮喘呼吸道功能及血清IL-17、TGF-β2水平的影响[J].湖南师范大学学报:医学版,2018,15(4):151-154.
[8] Van Herck M,Spruit M,Burtin C,et al.Fatigue is highly prevalent in patients with asthma and contributes to the burden of disease[J].J Clin Med,2018,7(12):471-473.
[9] Mehta D,Dagar A,Kishan J,et al.Common allergens prevalent in and around Ambala,Haryana:an intradermal study among patients with asthma and allergic rhinitis and atopic dermatitis[J].Indian J Dermatol,2018,63(4):311-317.
[10] 张焕英,于连峰,杨俊玲.支气管哮喘患者血清肿瘤坏死因子-α和透明质酸及羟脯氨酸水平表达及意义[J].中华实用诊断与治疗杂志,2016,30(10):1022-1024.
[11] 王建荣,冯瑞华,多力坤·木扎帕尔.白细胞介素-4受体基因多态性及IgE水平与哮喘预测指数相关性研究[J].中国当代儿科杂志,2015,17(12):1306-1310.
[12] 易绘,梁亚勇,肖奕青,等.婴幼儿和儿童哮喘过敏原IgE检测及临床意义[J].中国免疫学杂志,2019,35(3):340-344.
[13] 郑明睿,刘海霞,党亚洁,等.烟曲霉暴露对哮喘大鼠气道炎症、气道反应性及血清总IgE水平的影响[J].中国呼吸与危重监护杂志,2015,14(1):27-31.
[14] 朱湘芸,王洵,赵弘卿.支气管哮喘患儿血清TNF-α、IgE水平变化及其与肺炎支原体感染的关系[J].山东医药,2017,57(1):79-80.
[15] 管锡富.布地奈德雾化吸入联合孟鲁司特治疗小儿哮喘急性发作的疗效观察[J].中国妇幼保健,2017,32(4):759-761.
[16] 赵俊伟,时光,平杰丹,等.支气管哮喘患者外周血单个核细胞TIPE2表达对组织因子的负调控作用[J].中华医学杂志,2018,98(36):2889-2893.
PDF(679 KB)
